Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo
Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo
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DOI：
10.1117/1.jbo.18.6.060508
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发表时间：
2013-06-01
影响因子：
3.5
通讯作者：
Wang, Ruikang K.
中科院分区：
文献类型：
--
作者：
Liu, Rong;Qin, Jia;Wang, Ruikang K.
激光散斑成像被广泛用于监测体内组织床内的功能性血液灌注，但传统上即使在探测器暴露时间较长的情况下，也难以观察到小血管。我们报告了一种简单的方法，该方法使用动态斑点模式的运动对比来无创地可视化体内组织床内血流的分布。我们通过实验证明，与传统的激光散斑对比成像相比，运动对比度可以显著抑制静态散射的影响，从而增强包括毛细血管在内的功能血管的可见性。(C) 2013年中国光学仪器工程师学会
Laser speckle imaging is widely used to monitor functional blood perfusion within tissue beds in vivo but traditionally has difficulty visualizing small blood vessels even when the exposure time of the detector is long. We report a simple method that uses the motion contrast of dynamic speckle patterns to noninvasively visualize the distribution of blood flow within tissue beds in vivo. We experimentally demonstrate that the motion contrast can significantly suppress the effect of static scattering, leading to enhanced visibility of the functional blood vessels, including capillaries when compared to the traditional laser speckle contrast imaging. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)