Patterns of brain activation in people at risk for Alzheimer's disease
Patterns of brain activation in people at risk for Alzheimer's disease
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DOI：
10.1056/nejm200008173430701
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发表时间：
2000-08-17
影响因子：
158.5
通讯作者：
Small, GW
中科院分区：
文献类型：
--
作者：
Bookheimer, SY;Strojwas, MH;Small, GW
背景资料：载脂蛋白E基因（APOE）的等位基因是阿尔茨海默病的主要已知遗传危险因素，阿尔茨海默病是老年痴呆症的最常见原因。为了确定大脑对需要记忆的任务的反应与阿尔茨海默病的遗传风险之间的关系，我们对认知完整的老年人进行了APOE基因分型和大脑功能磁共振成像（MRI）。我们研究了30个实验对象年龄47 ~ 82岁，神经系统正常，其中16例为APOE β 4等位基因携带者，14例为APOE β 3等位基因纯合子。两组的平均年龄和教育水平相似。在功能性磁共振成像扫描过程中，当受试者记忆和回忆不相关的成对单词时，以及当受试者在这些时间段之间休息时，大脑激活模式被确定。两年后，在14名受试者的记忆进行了重新评估。结果：无论是幅度和程度的大脑激活记忆激活任务中受阿尔茨海默氏病影响的地区，包括左海马，顶叶，和前额区，是更大的载脂蛋白E β 4等位基因的携带者之间的载脂蛋白E β 3等位基因的携带者。在回忆过程中，APOE β 4等位基因携带者的海马区信号强度平均增加更大（1.03%对0.62%，P
Background: The epsilon 4 allele of the apolipoprotein E gene (APOE) is the chief known genetic risk factor for Alzheimer's disease, the most common cause of dementia late in life. To determine the relation between brain responses to tasks requiring memory and the genetic risk of Alzheimer's disease, we performed APOE genotyping and functional magnetic resonance imaging (MRI) of the brain in older persons with intact cognition.Methods: We studied 30 subjects (age, 47 to 82 years) who were neurologically normal, of whom 16 were carriers of the APOE epsilon 4 allele and 14 were homozygous for the APOE epsilon 3 allele. The mean age and level of education were similar in the two groups. Patterns of brain activation during functional MRI scanning were determined while subjects memorized and recalled unrelated pairs of words and while subjects rested between such periods. Memory was reassessed in 14 subjects two years later.Results: Both the magnitude and the extent of brain activation during memory-activation tasks in regions affected by Alzheimer's disease, including the left hippocampal, parietal, and prefrontal regions, were greater among the carriers of the APOE epsilon 4 allele than among the carriers of the APOE epsilon 3 allele. During periods of recall, the carriers of the APOE epsilon 4 allele had a greater average increase in signal intensity in the hippocampal region (1.03 percent vs. 0.62 percent, P