Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases
Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases
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DOI：
10.1038/modpathol.3800472
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发表时间：
2005-12-01
期刊：
影响因子：
7.5
通讯作者：
Clavel, CE
中科院分区：
文献类型：
--
作者：
Coissard, CJ;Besson, G;Clavel, CE
高危型人乳头瘤病毒（HPV）在很大程度上与宫颈癌的发生有关。它们在支气管肺癌中的作用尚不清楚。在本研究中，我们探讨了218新鲜冷冻肺肿瘤的HPV的存在与罗氏线印迹分析和表达的E6癌蛋白编码的mRNA在HPV阳性肿瘤。只有四个样本HPV检测阳性，一个低分化鳞状细胞癌和三个大细胞癌。E6 mRNA在这4个样本中均未检测到。我们的数据证实了西欧国家肺癌中HPV的低患病率，并且不支持HPV在这些癌症中的致癌作用。
High-risk human papillomaviruses (HPV) are largely implicated in the carcinogenesis of cervical carcinomas. Their role in bronchopulmonary carcinomas is still unclear. In the present study, we have explored 218 fresh frozen lung tumours for the presence of HPV with the Roche line blot assay and for the expression of mRNAs encoding E6 oncoprotein in HPV positive tumours. Only four samples were positive for HPV detection, one poorly differentiated squamous cell carcinoma and three large cell carcinomas. E6 mRNA was undetectable in these four samples. Our data confirm the low prevalence of HPV in lung carcinomas in Western European countries and do not plead in favour of a carcinogenic role for HPV in these carcinomas.