SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom.
SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom.
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英国狗和猫体内的 SARS-CoV-2 中和抗体。
DOI：
10.1101/2021.06.23.449594
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Smith SL
中科院分区：
文献类型：
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作者：
Smith SL
伴侣动物很容易感染SARS-CoV-2，英国也出现了零星的宠物感染病例。在这里，我们介绍了英国首次对狗和猫的SARS-CoV-2中和抗体进行的大规模血清学调查。一家大型兽医常规血液学诊断实验室在三个时间段收集了688份血清(犬454只，猫234只)的结果。这三个时期是：新冠肺炎之前(2020年1月)，英国人类感染的第一波期间(2020年4月至5月)和英国人类感染的第二波期间(2020年9月至2021年2月)。新冠肺炎前的血清和第一波的血清都检测为阴性。然而，在第二波采集的血清中，1.4%(n==4)的狗和2.2%(n==n2)的猫被检测出中和抗体呈阳性。检测呈阳性的动物数量很少，这表明宠物动物不太可能成为英国人类感染的主要宿主。然而，作为正在进行的人口健康监测行动的一部分，应对接触中的易感动物进行持续监测。
Companion animals are susceptible to SARS-CoV-2 infection and sporadic cases of pet infections have occurred in the United Kingdom. Here we present the first large-scale serological survey of SARS-CoV-2 neutralising antibodies in dogs and cats in the UK. Results are reported for 688 sera (454 canine, 234 feline) collected by a large veterinary diagnostic laboratory for routine haematology during three time periods; pre-COVID-19 (January 2020), during the first wave of UK human infections (April–May 2020) and during the second wave of UK human infections (September 2020–February 2021). Both pre-COVID-19 sera and those from the first wave tested negative. However, in sera collected during the second wave, 1.4% (n = 4) of dogs and 2.2% (n = 2) of cats tested positive for neutralising antibodies. The low numbers of animals testing positive suggests pet animals are unlikely to be a major reservoir for human infection in the UK. However, continued surveillance of in-contact susceptible animals should be performed as part of ongoing population health surveillance initiatives.