Detection approaches for multidrug resistance genes of leukemia.
Detection approaches for multidrug resistance genes of leukemia.
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白血病多药耐药基因的检测方法
DOI：
10.2147/dddt.s134529
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Chen B
中科院分区：
文献类型：
--
作者：
Du Y;Chen B
白血病是一种克隆性恶性造血干细胞疾病。它是第六大致命性癌症，占所有癌症的4%。白血病的主要治疗方式是化疗。虽然一些发病率高于白血病的癌症类型，如肺癌和胃癌，近年来死亡率大幅下降，但白血病并没有跟随这一趋势。在诊断为白血病的患者中，耐药通常被认为是有效化疗的主要临床障碍。目前已发现多种耐药机制，多药耐药(MDR)被认为是导致白血病化疗失败的最重要和最普遍的机制。为了逆转多药耐药，改善白血病预后，需要在初诊时采用有效的检测方法识别耐药基因。本文对已发表的检测白血病多药耐药的方法进行了全面的综述。为了更有效地治疗白血病，需要识别相关的多药耐药基因和早期检测这些基因的方法。
Leukemia is a clonal malignant hematopoietic stem cell disease. It is the sixth most lethal cancer and accounts for 4% of all cancers. The main form of treatment for leukemia is chemotherapy. While some cancer types with a higher incidence than leukemia, such as lung and gastric cancer, have shown a sharp decline in mortality rates in recent years, leukemia has not followed this trend. Drug resistance is often regarded as the main clinical obstacle to effective chemotherapy in patients diagnosed with leukemia. Many resistance mechanisms have now been identified, and multidrug resistance (MDR) is considered the most important and prevalent mechanism involved in the failure of chemotherapy in leukemia. In order to reverse MDR and improve leukemia prognosis, effective detection methods are needed to identify drug resistance genes at initial diagnosis. This article provides a comprehensive overview of published approaches for the detection of MDR in leukemia. Identification of relevant MDR genes and methods for early detection of these genes will be needed in order to treat leukemia more effectively.