MECHANISM OF ALTERED PATTERNS OF LEFT-VENTRICULAR FILLING DURING THE DEVELOPMENT OF CONGESTIVE-HEART-FAILURE
MECHANISM OF ALTERED PATTERNS OF LEFT-VENTRICULAR FILLING DURING THE DEVELOPMENT OF CONGESTIVE-HEART-FAILURE
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DOI：
10.1161/01.cir.89.5.2241
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发表时间：
1994-05-01
期刊：
影响因子：
37.8
通讯作者：
LITTLE, WC
中科院分区：
文献类型：
--
作者：
OHNO, M;CHENG, CP;LITTLE, WC
背景的机制，在左心室（LV）充盈模式的变化，在发展过程中的充血性心力衰竭（CHF）是不完全understood.Methods和结果我们研究了6个清醒的狗仪器测量LV和左心房（LA）的压力和LV容量CHF是由快速起搏引起的。在正常窦性心律期间连续测量4周的舒张充盈动力学。起搏后4天，舒张早期充盈率峰值从108+/-24降至88+/-27 mL/s（P
Background The mechanism of the alterations in the pattern of left ventricular (LV) filling during the development of congestive heart failure (CHF) is not fully understood.Methods and Results We studied six conscious dogs instrumented to measure LV and left atrial (LA) pressures and LV volume as CHF was induced by rapid pacing. Diastolic filling dynamics were serially measured over 4 weeks during normal sinus rhythm. Four days after we initiated pacing, the peak early diastolic filling rate decreased from 108+/-24 to 88+/-27 mL/s (P