IN-VIVO STIMULATION OF ENDOSTEAL BONE-FORMATION BY BASIC FIBROBLAST GROWTH-FACTOR IN RATS
IN-VIVO STIMULATION OF ENDOSTEAL BONE-FORMATION BY BASIC FIBROBLAST GROWTH-FACTOR IN RATS
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DOI：
10.3109/08977199308991583
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发表时间：
1993-01-01
期刊：
影响因子：
1.8
通讯作者：
KATO, K
中科院分区：
文献类型：
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作者：
MAYAHARA, H;ITO, T;KATO, K
静脉注射人碱性成纤维细胞生长因子（bFGF）2周，以0.1 mg/kg/天或更高的剂量水平刺激年轻和老年大鼠各种骨骼中的成骨细胞增殖和新骨形成。胫骨横截面的软X射线放射照片的形态测定表明，0.1 mg/kg/天剂量组骨干钙化骨面积增加约20%。Ca和羟脯氨酸含量在该剂量下显示统计学显著增加。新骨形成仅在骨内膜侧发现，并没有骨膜骨形成被found. Similar全身成骨潜能后，静脉注射FGF家族的其他生长因子，人酸性FGF和人肝素结合分泌型转化蛋白-1。上述结果表明，这些生长因子在骨丢失疾病如骨质疏松症中具有潜在的治疗作用。
Intravenous administration of human basic fibroblast growth factor (bFGF) for 2 weeks stimulated osteoblast proliferation and new bone formation in various skeletal bones in young and aged rats at dosage levels of 0.1 mg/kg/day and greater. Morphometry of the soft X-ray radiograms of cross sections of the tibia indicated about a 20% increase in the calcified bone area of the diaphysis at 0.1 mg/kg/day. The Ca and hydroxyproline contents showed statistically significant increases at this dosage. The new bone formation was found only on the endosteal side, and no periosteal bone formation was found. Similar systemic osteogenic potential was seen after intravenous administration of other growth factors of the FGF family, human acidic FGF and human heparin-binding secretory transforming protein-1. The above results suggest a potential therapeutic role for these growth factors in bone-loss diseases such as osteoporosis.