Surfactant therapy in preterm infants with respiratory distress syndrome and in near-term or term newborns with acute RDS.
Surfactant therapy in preterm infants with respiratory distress syndrome and in near-term or term newborns with acute RDS.
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DOI：
10.1038/sj.jp.7211474
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发表时间：
2006-05
期刊：
影响因子：
--
通讯作者：
Ramanathan R
中科院分区：
文献类型：
--
作者：
Ramanathan R
许多不同的动物源表面活性剂制剂以及合成表面活性剂可用于治疗患有呼吸窘迫综合征（RDS）的早产儿。含有表面活性剂相关蛋白质的天然改性表面活性剂似乎比不含蛋白质的合成表面活性剂更有效。与beractant相比，poractant alfa初始剂量较高（200 mg/kg）的比较试验似乎与FiO 2快速断奶、额外剂量需求减少以及妊娠<32周婴儿死亡率降低相关。早期抢救（<30分钟）表面活性剂治疗是一种有效的方法，以尽量减少过度治疗的一些早产儿谁可能不会发展RDS。表面活性物质治疗后迅速拔管鼻通气似乎比持续机械通气更有益。在患有急性RDS的近期或足月新生儿中，表面活性物质治疗已被证明在改善呼吸衰竭方面有70%的有效性。
Many different surfactant preparations derived from animal sources, as well as synthetic surfactants, are available for the treatment of preterm infants with respiratory distress syndrome (RDS). Natural, modified surfactants containing surfactant-associated proteins appear to be more effective than non-protein-containing synthetic surfactants. Comparative trials with poractant alfa at a higher initial dose of 200 mg/kg appear to be associated with rapid weaning of FiO2, less need for additional doses, and decreased mortality in infants <32 weeks gestation when compared with beractant. Early rescue (<30 min of age) surfactant therapy is an effective method to minimize over treatment of some preterm infants who may not develop RDS. Surfactant therapy followed by rapid extubation to nasal ventilation appears to be more beneficial than continued mechanical ventilation. In near-term or term newborns with acute RDS, surfactant therapy has been shown to be 70% effective in improving respiratory failure.
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影响因子：
5.1
作者：
Hudak, ML;Farrell, EE;Montgomery, P
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/0002-9378(95)90222-8
发表时间：
1995-07-01
影响因子：
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作者：
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影响因子：
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作者：
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