Redox-responsive magnetic nanovectors self-assembled from amphiphilic polymer and iron oxide nanoparticles for a remotely targeted delivery of paclitaxel
Redox-responsive magnetic nanovectors self-assembled from amphiphilic polymer and iron oxide nanoparticles for a remotely targeted delivery of paclitaxel
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由两亲聚合物和氧化铁纳米颗粒自组装的氧化还原响应磁性纳米载体，用于紫杉醇的远程靶向递送
DOI：
10.1039/d1tb00991e
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发表时间：
2021
影响因子：
7
通讯作者：
Cai Kaiyong
中科院分区：
文献类型：
--
作者：
Ding Xingwei;Jiang Wenyan;Dong Lina;Hong Can;Luo Zhong;Hu Yan;Cai Kaiyong
为了减少紫杉醇的副作用，促进紫杉醇在肿瘤部位的蓄积，基于二硫键连接的两亲性聚合物和磁性纳米粒子，制备了一种具有良好生物相容性的氧化还原响应型纳米载体。该系统在外加磁场作用下靶向肿瘤部位时，由于二硫键断裂，实现了PTX的释放。该纳米载体显著改善了肿瘤的吞噬作用，促进了肿瘤部位的蓄积，在体内外对肿瘤细胞具有有效的抑制作用。
To reduce the side effect of paclitaxel and enhance accumulation at the tumor site, a novel redox-responsive nanovector with excellent biocompatibility based on disulfide-linked amphiphilic polymer and magnetic nanoparticle was prepared. The system would realize PTX release due to breakage of the disulfide bond when being targeted to the tumor site by the external magnetic field. The nanovector significantly improved endocytosis and enhanced accumulation at the tumor site, with an effective inhibition of tumor cells in vitro and in vivo.