PURKINJE-CELL ACTIVITY DURING MOTOR LEARNING
PURKINJE-CELL ACTIVITY DURING MOTOR LEARNING
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DOI：
10.1016/0006-8993(77)90997-0
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
THACH, WT
中科院分区：
文献类型：
--
作者：
GILBERT, PFC;THACH, WT
猴子[Macaca .mu.ulatta]被训练抓住一个手柄，并通过弯曲或伸展手腕将其以水平弧形移动到中心位置。一个力矩马达施加力到手柄上，手柄以随机的间隔切换，交替地加载屈肌和伸肌。在每个负载开关处，手柄从中心位置短暂移位，然后由猴移回并再次稳定地保持在那里。记录从小脑浦肯野细胞（P细胞）的简单穗（SS）活动有关的任务。然后改变其中一个相反方向的负荷的大小，猴子在像以前一样有规律地执行之前用新的负荷进行大约12-100次试验。在具有1个已知负载和1个新负载的该时段期间，一些P小区在负载切换之后的特定时间经历复合尖峰（CS）频率的增加。这种增加的CS频率将持续与猴子在降低到接近其先前水平之前适应新负荷所采取的试验次数相似的试验次数。与CS频率增加相关，CS频率降低至接近其先前水平后，SS频率持续降低。运动学习可能发生在小脑中，通过由攀爬纤维输入引起的P细胞上的平行纤维突触的传输强度的变化。攀登纤维放电可能会导致平行纤维突触强度的降低。
Monkeys [Macaca .mu.ulatta] were trained to grasp a handle and move it in a horizontal arc to a central position by flexing or extending the wrist. A torque motor applied forces to the handle that switched at random intervals to alternately load flexor and extensor muscles. At each load switch, the handle was displaced transiently from the central position, and then moved back by the monkeys and held there steadily again. Recordings were made from cerebellar Purkinje cells (P-cells) whose simple spike (SS) activity was related to the task. The magnitude of one of the oppositely directed loads was then altered and the monkeys took about 12-100 trials with the novel load before performing as regularly as previously. During this period with 1 known and 1 novel load, some P-cells underwent increases in complex spike (CS) frequency at specific times after the load switch. This increased CS frequency would last for a similar number of trials as that taken by the monkey to adapt to the novel load before decreasing to near its previous level. Associated with the increased CS frequency there were decreases in SS frequency that persisted after the CS frequency had decreased to near its previous level. Motor learning may take place in the cerebellum through changes in the strength of transmission of parallel fiber synapses on P-cells caused by the climbing fiber input. Climbing fiber firing may cause a decrease in the strength of parallel fiber synapses.