Polar pattern formation induced by contact following locomotion in a multicellular system
Polar pattern formation induced by contact following locomotion in a multicellular system
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DOI：
10.7554/elife.53609
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发表时间：
2020-04-30
期刊：
影响因子：
7.7
通讯作者：
Shibata, Tatsuo
中科院分区：
文献类型：
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作者：
Hayakawa, Masayuki;Hiraiwa, Tetsuya;Shibata, Tatsuo
近年来，真核细胞集体迁移的生物物理机制得到了广泛的研究。一种诱导细胞相互关联运动的机制是接触抑制运动，细胞通过这种运动离开接触部位。在这里，我们报告了在接触部位的尾随行为，称为接触跟随运动(CFL)，可以在迁移细胞中诱导不平凡的集体行为。我们发现在缺乏趋化活性的突变体Dictyostelialcell中出现了一条显示极序的游动带。我们发现CFL是这种现象背后的细胞-细胞相互作用，这使得能够从理论上描述这种行波带是如何形成的。我们进一步证明，极序相由子集居数组成，这些子集居数表现出相对于带传播方向的特征横向运动。这些发现描述了一种新的细胞集体迁移机制，涉及细胞与细胞之间的相互作用，能够诱导具有极序的行波带。
Biophysical mechanisms underlying collective cell migration of eukaryotic cells have been studied extensively in recent years. One mechanism that induces cells to correlate their motions is contact inhibition of locomotion, by which cells migrating away from the contact site. Here, we report that tail-following behavior at the contact site, termed contact following locomotion (CFL), can induce a non-trivial collective behavior in migrating cells. We show the emergence of a traveling band showing polar order in a mutant Dictyostelium cell that lacks chemotactic activity. We find that CFL is the cell-cell interaction underlying this phenomenon, enabling a theoretical description of how this traveling band forms. We further show that the polar order phase consists of subpopulations that exhibit characteristic transversal motions with respect to the direction of band propagation. These findings describe a novel mechanism of collective cell migration involving cell-cell interactions capable of inducing traveling band with polar order.