High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains
High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains
复制标题
DOI：
10.1006/geno.2000.6442
复制
发表时间：
2001-02-15
期刊：
影响因子：
4.4
通讯作者：
Rapp, JP
中科院分区：
文献类型：
--
作者：
Cicila, GT;Garrett, MR;Rapp, JP
It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11 beta -hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11 beta -hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. (C) 2001 Academic Press.
