Fitting structure to function in gene regulatory networks.
Fitting structure to function in gene regulatory networks.
复制标题
使结构适应基因调控网络的功能。
DOI：
10.1007/s40656-017-0164-z
复制
发表时间：
2017
影响因子：
2
通讯作者：
Rothenberg,EllenV
中科院分区：
文献类型：
--
作者：
Rothenberg,EllenV
转录调控级联是所有发育系统中向前驱动的共同来源。连续阶段基因表达复杂性和特异性的增加是基于细胞中已表达的转录因子的各种组合的协作以开启新基因，并且各个阶段作用和新表达的转录因子之间的逻辑关系最好可视化为基因调控网络。然而，在不同发育环境中使用的基因调控网络是实际上通过不同规则集运行的过程的基础，这些规则影响各个网络节点的动力学、同步性和逻辑特性。将果蝇和海胆的早期胚胎发育与干细胞的成年哺乳动物造血发育进行对比，可以发现主要差异在于转录因子剂量依赖性、抑制的沉默或抑制影响，以及细胞调控历史对给定细胞类型中转录因子作用可及的基因组部分的影响。这些不同的特征不仅影响能够阐明各自生物系统发育机制的模型种类，而且反映了这些生物系统优化发育不同方面的进化需求。
Cascades of transcriptional regulation are the common source of the forward drive in all developmental systems. Increases in complexity and specificity of gene expression at successive stages are based on the collaboration of varied combinations of transcription factors already expressed in the cells to turn on new genes, and the logical relationships between the transcription factors acting and becoming newly expressed from stage to stage are best visualized as gene regulatory networks. However, gene regulatory networks used in different developmental contexts underlie processes that actually operate through different sets of rules, which affect the kinetics, synchronicity, and logical properties of individual network nodes. Contrasting early embryonic development in flies and sea urchins with adult mammalian hematopoietic development from stem cells, major differences are seen in transcription factor dosage dependence, the silencing or damping impacts of repression, and the impact of cellular regulatory history on the parts of the genome that are accessible to transcription factor action in a given cell type. These different features not only affect the kinds of models that can illuminate developmental mechanisms in the respective biological systems, but also reflect the evolutionary needs of these biological systems to optimize different aspects of development.