Remember the Source: Dissociating Frontal and Parietal Contributions to Episodic Memory
Remember the Source: Dissociating Frontal and Parietal Contributions to Episodic Memory
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DOI：
10.1162/jocn.2009.21242
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发表时间：
2010-02-01
影响因子：
3.2
通讯作者：
Petersen, Steve E.
中科院分区：
文献类型：
--
作者：
Donaldson, David I.;Wheeler, Mark E.;Petersen, Steve E.
事件相关的功能磁共振成像研究表明，情景记忆检索调节外侧和内侧顶叶皮层、背侧额叶中回（MFG）和前部pfc。这些区域对识别旧单词的反应比正确拒绝新单词的反应更强烈，表明检索成功与神经相关。尽管对检索成功区域进行了大量的研究，但它们在检索中的作用仍然很大程度上是未知的。这里我们问的问题是，这些区域在多大程度上执行内存特定操作？如果是这样，它们对成功检索是否同样敏感，或者是否也涉及到错误检测等其他因素？我们通过测试检索成功区域的活动是否与任务特定的偶然性（即，感知目标性）或助记相关性（例如，源上下文的检索）相关来研究这个问题。为了做到这一点，我们使用了一个源记忆任务，需要区分记住的目标和记住的非目标。对于一个给定的区域，神经活动受情境因素（如目标状态）的调节可能表明其具有更广泛的领域作用；同样，与错误检测相关的活动调节表明，它的作用是监测和控制，而不是从记忆本身积累证据。我们发现顶叶检索成功区在接收正确源反应时比接收错误源反应时表现出更大的活动，而额叶检索成功区在接收错误源反应时最活跃，这表明后叶区域发出成功检索信号，而额叶区域监测检索结果。此外，在任何检索成功区域，感知的靶向性都无法调节fMRI活动，这表明这些区域是检索特异性的。我们讨论了这些区域可能支持的不同功能，并提出了一个累加器模型，该模型捕获了额叶和顶叶检索成功区域中不同的反应模式。
Event-related fMRI studies reveal that episodic memory retrieval modulates lateral and medial parietal cortices, dorsal middle frontal gyrus (MFG), and anterior PFC. These regions respond more for recognized old than correctly rejected new words, suggesting a neural correlate of retrieval success. Despite significant efforts examining retrieval success regions, their role in retrieval remains largely unknown. Here we asked the question, to what degree are the regions performing memory-specific operations? And if so, are they all equally sensitive to successful retrieval, or are other factors such as error detection also implicated? We investigated this question by testing whether activity in retrieval success regions was associated with task-specific contingencies (i.e., perceived targetness) or mnemonic relevance (e. g., retrieval of source context). To do this, we used a source memory task that required discrimination between remembered targets and remembered nontargets. For a given region, the modulation of neural activity by a situational factor such as target status would suggest a more domain-general role; similarly, modulations of activity linked to error detection would suggest a role in monitoring and control rather than the accumulation of evidence from memory per se. We found that parietal retrieval success regions exhibited greater activity for items receiving correct than incorrect source responses, whereas frontal retrieval success regions were most active on error trials, suggesting that posterior regions signal successful retrieval whereas frontal regions monitor retrieval outcome. In addition, perceived targetness failed to modulate fMRI activity in any retrieval success region, suggesting that these regions are retrieval specific. We discuss the different functions that these regions may support and propose an accumulator model that captures the different pattern of responses seen in frontal and parietal retrieval success regions.