Comparative pharmacokinetics of florfenicol in healthy and Pasteurella multocida-infected Gaoyou ducks
Comparative pharmacokinetics of florfenicol in healthy and Pasteurella multocida-infected Gaoyou ducks
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氟苯尼考在健康鸭和多杀性巴氏杆菌感染高邮鸭体内的药代动力学比较
DOI：
10.1111/jvp.12761
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发表时间：
2019-05-01
影响因子：
1.3
通讯作者：
Wang, Zhiqiang
中科院分区：
文献类型：
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作者：
Lan, Weixuan;Xiao, Xia;Wang, Zhiqiang
多杀性巴氏杆菌是禽类霍乱的致病菌，氟苯尼考（FF）对多杀性巴氏杆菌具有较强的抑菌活性，被广泛应用于家禽业。在本研究中，我们建立了鸭多杀性假单胞菌感染模型，研究了口服30 mg/kg体重后FF在血清和肺组织中的药代动力学。感染鸭的最大C-max浓度（13.88 +/- 2.70 μ g/ml）低于健康对照动物（17.86 +/- 1.57 μ g/ml）。相比之下，健康和患病动物的平均停留时间（MRT: 2.35 +/- 0.13 vs. 2.27 +/- 0.18 hr）和消除半衰期（T-1/2 β: 1.63 +/- 0.08 vs. 1.57 +/- 0.12 hr）相似。结果表明，FF在健康鸭0-12小时的浓度曲线下面积（AUC（0-12小时））显著大于感染鸭（49.47 +/- 5.31 vs. 34.52 +/- 8.29 mu g hr/ml）。两组间肺组织中FF的药动学差异与血清药动学差异相关。健康鸭肺组织的C-max和AUC（0 ~ 12 hr）值均高于病鸭。感染鸭和健康鸭肺组织中FF的浓度均比血清中FF的浓度高约1.2倍，表明FF对治疗呼吸道感染有效。
Pasteurella multocida is the causative agent of fowl cholera, and florfenicol (FF) has potent antibacterial activity against P. multocida and is widely used in the poultry industry. In this study, we established a P. multocida infection model in ducks and studied the pharmacokinetics of FF in serum and lung tissues after oral administration of 30 mg/kg bodyweight. The maximum concentrations reached (C-max) were lower in infected ducks (13.88 +/- 2.70 mu g/ml) vs. healthy control animals (17.86 +/- 1.57 mu g/ml). In contrast, the mean residence time (MRT: 2.35 +/- 0.13 vs. 2.27 +/- 0.18 hr) and elimination half-life (T-1/2 beta: 1.63 +/- 0.08 vs. 1.57 +/- 0.12 hr) were similar for healthy and diseased animals, respectively. As a result, the area under the concentration curve for 0-12 hr (AUC(0-12 hr)) for FF in healthy ducks was significantly greater than that in infected ducks (49.47 +/- 5.31 vs. 34.52 +/- 8.29 mu g hr/ml). The pharmacokinetic differences of FF in lung tissues between the two groups correlated with the serum pharmacokinetic differences. The C-max and AUC(0-12 hr) values of lung tissue in healthy ducks were higher than those in diseased ducks. The concentration of FF in lung tissues was approximately 1.2-fold higher than that in serum both in infected and healthy ducks indicating that FF is effective in treating respiratory tract infections in ducks.