EFFECT OF LONG-TERM TREATMENT WITH INHALED CORTICOSTEROIDS AND BETA-AGONISTS ON THE BRONCHIAL RESPONSIVENESS IN CHILDREN WITH ASTHMA
EFFECT OF LONG-TERM TREATMENT WITH INHALED CORTICOSTEROIDS AND BETA-AGONISTS ON THE BRONCHIAL RESPONSIVENESS IN CHILDREN WITH ASTHMA
复制标题
DOI：
10.1016/s0091-6749(87)80163-x
复制
发表时间：
1987-04-01
影响因子：
14.2
通讯作者：
NEIJENS, HJ
中科院分区：
文献类型：
--
作者：
KERREBIJN, KF;VANESSENZANDVLIET, EEM;NEIJENS, HJ
气道炎症被认为是支气管反应性（BR）增加的重要决定因素。我们检验了吸入消炎药（即布地奈德）治疗而不吸入β的假设。-激动剂（即特布他林）可降低哮喘患儿的BR，且支气管收缩很小或没有支气管收缩。12例患者用布地奈德治疗，7例用特布他林治疗，疗程6个月。接受布地奈德治疗的11例患者BR下降，7例患者BR显著。接受特布他林治疗的患者BR均未下降。布地奈德组的FEV1略有增加，但特布他林组保持不变。除1例患者使用特布他林外，临床效果良好。我们的结论是，吸入皮质类固醇而不吸入β。-激动剂可降低大多数哮喘患儿的持续性BR。
Airway inflammation is assumed to be an important determinant in increased bronchial responsiveness (BR). We tested the hypothesis that treatment with an inhaled anti-inflammatory drug (i.e., budesonide) but not with an inhaled .beta.-agonist (i.e., terbutaline) would reduce BR in children with asthma and with minimal or no bronchoconstriction. Twelve patients were treated with budesonide and seven with terbutaline for 6 months. BR decreased in 11 patients receiving budesonide and was significant in seven patients. BR decreased in none of the patients receiving terbutaline. FEV1 demonstrated a small increase with budesonide but remained unchanged with terbutaline. Except in one patient who received terbutaline, the clinical effect was good. We conclude that inhaled corticosteroids but not inhaled .beta.-agonists will decrease persistent BR in most children with asthma.