Generalized morphea. I. Histology of the dermis and subcutaneous tissue.
Generalized morphea. I. Histology of the dermis and subcutaneous tissue.
复制标题
广义硬斑病。
作者：
R. Fleischmajer;A. Nedwich
在全身性硬斑病的早期阶段，有一种炎症反应，主要涉及外泌汗腺和皮下组织周围的脂肪。细胞浸润由淋巴细胞、浆细胞和组织细胞型细胞组成。还观察到具有生发中心的类棘状卵泡。炎症阶段之后是透明化结缔组织替代皮下组织。这个过程可能是导致这种疾病皮肤硬结的原因。
During the early stage of generalized morphea there is an inflammatory reaction involving primarily the fat around the eccrine sweat glands and the subcutaneous tissue. The cellular infiltrate consist of lymphocytes, plasma cells, and histocytic type cells. Lymphoid follicles with germinal centers were also noted. The inflammatory stage is followed by the replacement of the subcutaneous tissue by hyalinized connective tissue. This process is probably responsible for the skin induration in this disease.