Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy.
Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy.
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DOI：
10.1111/aji.12265
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发表时间：
2014-09
期刊：
影响因子：
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通讯作者：
Meeker JD
中科院分区：
文献类型：
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作者：
Ferguson KK;McElrath TF;Chen YH;Mukherjee B;Meeker JD
以前的研究已经调查了炎症标志物作为早产预测因子的效用，但没有一项研究比较了无并发症和早产之间的水平趋势。我们通过巢式病例对照研究探讨了孕妇血浆细胞因子（包括IL-1β、IL-6、IL-10和TNF-α）以及C反应蛋白的纵向变化。IL-6与自发性早产几率增加相关，自发性早产定义为自发性早产和/或胎膜早破。在怀孕后期，相关性最强。IL-10与胎盘介导的早产（定义为先兆子痫或宫内生长受限）的几率增加相关，并且在妊娠结束时的比值比也最高。母体炎症标志物与早产风险增加相关，且关系因早产病因和样本采集时的胎龄而异。
Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. We explored longitudinal changes in plasma cytokines, including IL-1β, IL-6, IL-10, and TNF-α, as well as C-reactive protein in pregnant women from a nested case-control study. IL-6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL-10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy. Maternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.