Activity-dependent enhancement of presynaptic inhibition in Aplysia sensory neurons.
Activity-dependent enhancement of presynaptic inhibition in Aplysia sensory neurons.
复制标题
海兔感觉神经元突触前抑制的活动依赖性增强。
DOI：
10.1126/science.2538924
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hawkins,RD
中科院分区：
文献类型：
--
作者：
Small,SA;Kandel,ER;Hawkins,RD
尾部电击对海兔的虹吸感觉神经元产生短暂的突触前抑制和更持久的突触前促进。这种促进作用经历了活动依赖性增强，这被认为有助于鳃和虹吸缩回反射的经典调节。现在还表明，当感觉神经元中的动作电位活动与抑制性递质配对时，感觉神经元的抑制会经历活动依赖性增强。这种效应似乎涉及与正常突触前抑制相同的细胞机制的放大。这些结果表明，活性依赖性增强可能是关联细胞机制的一般类型。
Tail shock produces transient presynaptic inhibition and longer lasting presynaptic facilitation of the siphon sensory neurons inAplysia. The facilitation undergoes activity-dependent enhancement that is thought to contribute to classical conditioning of the gill- and siphon-withdrawal reflex. Inhibition of the sensory neurons has now also been shown to undergo activity-dependent enhancement when action potential activity in the sensory neurons is paired with inhibitory transmitter. This effect appears to involve an amplification of the same cellular mechanisms that are involved in normal presynaptic inhibition. These results suggest that activity-dependent enhancement may be a general type of associative cellular mechanism.