Soy food consumption and breast cancer prognosis.
Soy food consumption and breast cancer prognosis.
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DOI：
10.1158/1055-9965.epi-10-1041
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Pierce JP
中科院分区：
文献类型：
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作者：
Caan BJ;Natarajan L;Parker B;Gold EB;Thomson C;Newman V;Rock CL;Pu M;Al-Delaimy W;Pierce JP
与早期的临床研究表明大豆可能促进乳腺肿瘤生长相反，最近的两项研究表明，含大豆的食物与乳腺癌预后无关。利用妇女健康饮食和生活（WHEL）研究的数据，我们研究了大豆摄入量对乳腺癌预后的影响。3088名乳腺癌幸存者，在1991年至2000年期间被诊断为早期乳腺癌，并参加了WHEL，平均随访时间为7.3年。异黄酮摄入量在诊断后使用食物频率问卷（FFQ）进行测量。女性每半年自我报告一次新的结局事件，然后通过医疗记录和/或死亡证明进行验证。计算代表第二次乳腺癌事件或死亡与大豆摄入之间关联的风险比（HR）和95%置信区间（CI），使用延迟进入考克斯比例风险模型对研究组和其他协变量进行调整。随着摄入量的增加，死亡风险降低（趋势p =0.02）。女性在最高水平的维生素E摄入量（>16.3毫克维生素E）-有一个非显着的死亡风险降低54%。我们的研究是第三个报告大豆食品对乳腺癌预后没有不良影响的流行病学研究。这些研究在种族构成（两个来自美国，一个来自中国）和大豆消费水平和类型上各不相同，综合起来，提供了必要的流行病学证据，表明临床医生不再需要建议被诊断患有乳腺癌的女性不要食用大豆。
Contrary to earlier clinical studies suggesting soy may promote breast tumor growth, two recent studies demonstrate that soy-containing foods are not adversely related to breast cancer prognosis. Using data from the Women’s Healthy Eating and Living (WHEL) study, we examined the effect of soy intake on breast cancer prognosis. 3088 breast cancer survivors, diagnosed between 1991 and 2000 with early stage breast cancer and participating in WHEL were followed for a median of 7.3 years. Isoflavone intakes were measured post-diagnosis using a food frequency questionnaire (FFQ). Women self-reported new outcome events semi-annually which were then verified by medical records and/or death certificates. Hazard ratios (HR) and 95% confidence intervals (CI) representing the association between either a second breast cancer event or death and soy intake were computed, adjusting for study group and other covariates using the delayed entry Cox proportional hazards model. As isoflavone intake increased, risk of death decreased (p for trend=0.02). Women at the highest levels of isoflavone intake (>16.3 mg isoflavones) - had a non-significant 54% reduction in risk of death. Our study is the third epidemiological study to report no adverse effects of soy foods on breast cancer prognosis. These studies, taken together, which vary in ethnic composition (two from the US and one from China) and by level and type of soy consumption, provide the necessary epidemiological evidence that clinicians no longer need to advise against soy consumption for women diagnosed with breast cancer.