Dioxin exposure and sexual dimorphism of gaze behavior in prepubertal Vietnamese children living in Da Nang, a hot spot for dioxin contamination
Dioxin exposure and sexual dimorphism of gaze behavior in prepubertal Vietnamese children living in Da Nang, a hot spot for dioxin contamination
复制标题
DOI：
10.1016/j.scitotenv.2020.141083
复制
发表时间：
2020-12-20
影响因子：
9.8
通讯作者：
Nishijo, Hisao
中科院分区：
文献类型：
--
作者：
Thao Ngoc Pham;Nishijo, Muneko;Nishijo, Hisao
先前的研究报告表明，二恶英暴露改变了青春期前儿童游戏行为的性二态性。我们的目的是研究在调整皮毛唾液睾酮（T）后，围产期二恶英暴露（由母乳中的二恶英指示）对凝视行为性二态性的影响。研究对象为越南一个因喷洒除草剂而受二恶英污染的热点地区的青春期前儿童，我们使用眼动追踪法对172名8-9岁儿童（100名男孩和72名女孩）的凝视行为进行了评估。向所有儿童展示两组15对图片，一组面向男孩，一组面向女孩，其中包括5对玩具照片（非生物刺激）和10对人体线条画（生物刺激）。使用Tobii Studio软件提取每张图片的总注视时间，并将注视行为的女性指数定义为每个刺激物的女孩与男孩取向版本的总注视时间的比率。当观看非生物刺激物时，女性指数得分仅在女孩中显著增加TCDD（β = 0294）。然而，对于生物刺激，男孩的TEQ-PCDD/Fs（β = 0.269）和女孩的TCDD（β = 0.286）的女性指数得分显著增加。这些协会是显着的，即使调整唾液T水平，这是负相关的一些二恶英同系物的女孩。此外，增加女性指数分数的生物刺激与较低的认知分数的手运动和语序测试的男孩和面孔识别测试的女孩检查在5岁的age.In结论，这些结果表明，围产期二恶英暴露可能会增加视觉兴趣，女孩为导向的对象，通过在青春期前的越南儿童的认知能力受损。在男孩中，PCDD同源物与凝视行为独立于T水平相关，而在女孩中，这只是TCDD水平的情况。(C)2020 Elsevier B. V.保留所有权利。
Previous studies have reported that dioxin exposure alters sexual dimorphism of play behavior in pre-pubertal children. We aimed to investigate the effects of perinatal dioxin exposure, indicated by dioxins in breast milk, on sexual dimorphism of gaze behavior after adjusting fur salivary testosterone (T). Participants were prepubertal children in a hot spot for dioxin contamination originating from herbicide spraying in Vietnam.We used eye tracking to assess gaze behavior in 172 children (100 boys and 72 girls) aged 8-9 years. Two sets of 15 pairs of pictures, one oriented towards boys and one oriented towards girls, containing 5 pairs of toy photos (non-biological stimuli) and 10 pairs of human line drawings (biological stimuli) were shown to all children. The total fixation duration for each picture was extracted using Tobii studio software and a feminine index of gaze behavior was defined as the ratio of the summed fixation duration for the girl- vs boy-oriented versions of each stimuli.When viewing non-biological stimuli, feminine index scores significantly increased with TCDD (beta = 0294) in girls only. For biological stimuli, however, feminine index scores significantly increased with TEQ-PCDD/Fs (beta = 0.269) in boys and with TCDD in girls (beta = 0.286). These associations were sig,nificant even after adjusting for salivary T levels, which were inversely associated with some dioxin congeners in girls. In addition, increased feminine index scores for biological stimuli were associated with lower cognitive scores for hand-movement and word-order tests in boys and for face-recognition tests in girls examined at 5 years of age.In conclusion, these results suggest that perinatal dioxin exposure may increase visual interest in girl-oriented objects through impairment of cognitive abilities in pre-pubertal Vietnamese children. PCDD congeners were associated with gaze behavior independently of T levels in boys, while this was only Lhe case for TCDD levels in girls. (C) 2020 Elsevier B.V. All rights reserved.