Protein-passivated Fe3O4 nanoparticles:: low toxicity and rapid heating for thermal therapy
Protein-passivated Fe3O4 nanoparticles:: low toxicity and rapid heating for thermal therapy
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DOI：
10.1039/b718745a
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Rotello, Vincent M.
中科院分区：
文献类型：
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作者：
Samanta, Bappaditya;Yan, Haoheng;Rotello, Vincent M.
热疗是一种很有前途的微创消除实体瘤的技术。在这里，我们报告的蛋白质涂层的氧化铁纳米粒子（12纳米核心）的制造用作热治疗剂。这些白蛋白钝化的NP在生理条件下是稳定的，在交变磁场（AMF）暴露时具有快速加热和细胞杀伤能力。作用方式具有特异性：未观察到不含AMF的颗粒或不含颗粒的AMF暴露的可测量细胞毒性。
Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.