Altered Resting-State Network Connectivity in Congenital Blind
Altered Resting-State Network Connectivity in Congenital Blind
复制标题
先天性盲人的静息态网络连接发生改变
DOI：
10.1002/hbm.22350
复制
发表时间：
2014-06-01
影响因子：
4.8
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
--
作者：
Wang, Dawei;Qin, Wen;Yu, Chunshui
先天性盲人的大脑经历了一系列结构和功能的改变，要么是由于出生时视力丧失导致的视觉通路萎缩等不良后果，要么是与环境有效互动的代偿性可塑性。然而，到目前为止，人们对CB中休息状态网络(RSN)功能结构的变化知之甚少。本研究旨在利用独立成分分析(ICA)对静息状态下的功能性磁共振数据进行分析，以探讨正常人和视力正常对照(SC)在网络内和网络间的连通性差异。与SC相比，CB显著增加了突起网络(SN)和枕叶皮质内的网络连接。此外，CB显示黑质与额顶神经网络(FPN)及FPN与枕叶皮质之间的网络连通性增强，但枕叶皮质与感觉运动网络之间的网络连通性降低。这些发现表明，CB在功能网络水平上经历了大规模的重组。更重要的是，CB的SN、FPN和枕叶皮质的内部和内部网络连接增强可能会提高他们识别显著刺激、启动执行功能和自上而下控制注意力的能力，这对CB引导适当的行为和更好地适应环境是至关重要的。Hum Brain Mapp 35：2573-2581,2014。(C)2013年威利期刊公司。
The brain of congenital blind (CB) has experienced a series of structural and functional alterations, either undesirable outcomes such as atrophy of the visual pathway due to sight loss from birth, or compensatory plasticity to interact efficiently with the environment. However, little is known, so far, about alterations in the functional architecture of resting-state networks (RSNs) in CB. This study aimed to investigate intra- and internetwork connectivity differences between CB and sighted controls (SC), using independent component analysis (ICA) on resting state functional MRI data. Compared with SC, CB showed significantly increased network connectivity within the salience network (SN) and the occipital cortex. Moreover, CB exhibited enhanced internetwork connectivity between the SN and the frontoparietal network (FPN) and between the FPN and the occipital cortex; however, they showed decreased internetwork connectivity between the occipital cortex and the sensorimotor network. These findings suggest that CB experience large scale reorganization at the level of the functional network. More importantly, the enhanced intra- and internetwork connectivity of the SN, FPN, and occipital cortex in CB may improve their abilities to identify salient stimuli, to initiate the executive function, and to top-down control of attention, which are critical for the CB to guide appropriate behavior and to better adaption to the environment. Hum Brain Mapp 35:2573-2581, 2014. (c) 2013 Wiley Periodicals, Inc.