Genetic basis of non-syndromic anomalies of human tooth number
Genetic basis of non-syndromic anomalies of human tooth number
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DOI：
10.1016/j.archoralbio.2012.01.005
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发表时间：
2012-07-01
影响因子：
3
通讯作者：
La Monaca, Camilla
中科院分区：
文献类型：
--
作者：
Galluccio, Gabriella;Castellano, Monica;La Monaca, Camilla
牙齿器官发生是通过一系列有序的诱导事件发展的，涉及基因和 BMP、FGF、SHH 和 MINT 代表调节上皮间质相互作用的主要信号通路。此外，遗传学和分子生物学的进展表明，超过300个基因参与牙齿发育的不同阶段。与牙发生有关的基因突变是许多牙齿异常的原因，包括许多可能与其他全身骨骼或器质表现（综合征性牙齿异常）或无关（非综合征性牙齿异常）相关的牙齿异常。后者的遗传发育机制的知识具有重要意义。了解非综合征性牙齿异常的发病机制也将阐明牙齿在颅面发育中的作用，这将对先天性畸形的诊断、治疗和预后以及最终与其他严重疾病的关联做出重要贡献。该领域的未来研究可能会导致医生测试的发展，以便对这些异常进行早期诊断。 (C) 2012 Elsevier Ltd. 保留所有权利。
Teeth organogenesis develops through a well-ordered series of inductive events involving genes and BMP, FGF, SHH and MINT represent the main signalling pathways that regulate epithelial-mesenchymal interactions. Moreover, progress in genetics and molecular biology indicates that more than 300 genes are involved in different phases of teeth development. Mutations in genes involved in odontogenesis are responsible for many dental anomalies, including a number of dental anomalies that can be associated with other systemic skeletal or organic manifestations (syndromic dental anomalies) or not (non-syndromic dental anomalies). The knowledge of the genetic development mechanisms of the latter is of major interest. Understanding the mechanisms of pathogenesis of non-syndromic teeth anomalies would also clarify the role of teeth in craniofacial development, and this would represent an important contribution to the diagnosis, treatment and prognosis of congenital malformations, and the eventual association to other severe diseases. Future research in this area is likely to lead to the development of tests for doctors to formulate an early diagnosis of these anomalies. (C) 2012 Elsevier Ltd. All rights reserved.