Phonological processing in post-lingual deafness and cochlear implant outcome
Phonological processing in post-lingual deafness and cochlear implant outcome
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DOI：
10.1016/j.neuroimage.2009.11.013
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发表时间：
2010-02-15
期刊：
影响因子：
5.7
通讯作者：
Giraud, A. L.
中科院分区：
文献类型：
--
作者：
Lazard, D. S.;Lee, H. J.;Giraud, A. L.
髋关节植入物效果良好，但临床医生常规可用的数据并不能完全解释结果，并且仍然不可预测。更深入地了解决定人工耳蜗植入后临床恢复的神经机制是必要的，因为它们可以为准确的个体预后提供背景。在这项针对成年语聋患者的研究中，我们发现，虽然临床数据仅提供预后趋势，但功能磁共振成像数据可以前瞻性地区分植入体表现良好和较差的患者。我们发现，这些聋人人工耳蜗（CI）的候选人谁将成为良好的表演者依赖于背音位路线时，执行押韵的任务，书面定期的话。相比之下，那些表现不佳的人涉及腹侧颞额叶路线来执行相同的任务，并且异常地招募右侧缘上回，这是一个与经典语音区域对侧的区域。这些功能模式表明，耳聋或增强“正常”的语音加工，或促使语音加工的词汇语义加工的替代。因此，这些研究结果表明，一个简单的行为术前探索语音策略在阅读，以确定哪条路线是主要使用的CI候选人，可能会卓有成效地告知的结果。(C)2009 Elsevier Inc. All rights reserved.
Cochlear implants work well, yet the outcome is not fully accounted by the data routinely available to the clinician, and remains unpredictable. A more in-depth understanding of the neural mechanisms that determine the clinical recovery after cochlear implantation is warranted, as they may provide the background for an accurate individual prognosis. In this study in post-lingually deaf adults, we show that while clinical data offer only prognosis trends, fMRI data can prospectively distinguish good from poor implant performers. We show that those deaf cochlear implant (CI) candidates who will become good performers rely on a dorsal phonological route when performing a rhyming task on written regular words. In contrast, those who will become poor performers involve a ventral temporo-frontal route to perform the same task, and abnormally recruit the right supramarginal gyrus, a region that is contralateral to classical phonological regions. These functional patterns reveal that deafness either enhances "normal" phonological processing, or prompts a substitution of phonological processing by lexico-semantic processing. These findings thus suggest that a simple behavioral pre-operative exploration of phonological strategies during reading, to determine which route is predominantly used by CI candidates, might fruitfully inform the outcome. (C) 2009 Elsevier Inc. All rights reserved.