Association between glaucomatous optic disc and depressive symptoms independent of light exposure profiles: a cross-sectional study of the HEIJO-KYO cohort
Association between glaucomatous optic disc and depressive symptoms independent of light exposure profiles: a cross-sectional study of the HEIJO-KYO cohort
复制标题
青光眼视盘与抑郁症状之间的关联与光照情况无关：HEIJO-KYO 队列的横断面研究
DOI：
10.1136/bjophthalmol-2018-312176
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发表时间：
2018
影响因子：
4.1
通讯作者：
Ogata Nahoko
中科院分区：
文献类型：
--
作者：
Yoshikawa Tadanobu;Obayashi Kenji;Miyata Kimie;Ueda Tetsuo;Kurumatani Norio;Saeki Keigo;Ogata Nahoko
背景青光眼可能会导致生理和行为昼夜节律失调，这是因为环境光的主要接收器--固有的光敏性视网膜神经节细胞的丧失。虽然研究表明青光眼患者中抑郁症的发病率很高，但尚不清楚这种关联是否独立于光暴露情况作为一个重要的混杂因素。方法在这项以社区为基础的队列研究中，对770名老年人(平均年龄70.9岁)进行了横断面研究，用眼底照片评估了青光眼视盘，并用简明版老年抑郁量表(GDS)评估了抑郁症状。结果观察到114名受试者出现抑郁症状(≥评分为6分)，患病率为14.8%；40名受试者出现青光眼视盘，患病率为5.2%。有青光眼视盘组抑郁症状的发生率显著高于无视盘组(分别为30.0%和14.0%；p=0.005)。对白天和夜间光暴露等潜在混杂因素进行多因素Logistic回归分析，发现有青光眼视盘组抑郁症状的OR显著高于无视盘组(OR2.45，95%CI1.18~5.08；p=0.016)。结论在这一普通老年人群中，青光眼视盘与抑郁症状的发生率显著相关，而与包括日常光暴露情况在内的许多潜在混杂因素无关。
BackgroundGlaucoma may cause physiological and behavioural circadian misalignment because of the loss of intrinsically photosensitive retinal ganglion cells, the primary receptors of environmental light. Although studies have suggested a high prevalence of depression in patients with glaucoma, it is unclear whether the association is independent of the light exposure profiles as an important confounding factor.MethodsIn this cross-sectional study of a community-based cohort of 770 elderly individuals (mean age, 70.9 years), glaucomatous optic discs were assessed using fundus photographs and depressive symptoms were assessed using the short version of the Geriatric Depression Scale (GDS). Daytime and night-time ambient light exposures were objectively measured for 2 days.ResultsDepressive symptoms (GDS score ≥6) were observed in 114 participants (prevalence, 14.8%) and glaucomatous optic discs were detected in 40 participants (prevalence, 5.2%). The prevalence of depressive symptoms was significantly higher in the group with glaucomatous optic disc than in the group without it (30.0% vs 14.0%, respectively; p=0.005). Multivariable logistic regression analysis adjusted for potential confounding factors, including daytime and night-time light exposures, revealed that the OR for depressive symptoms was significantly higher in the group with glaucomatous optic disc than in the group without it (OR 2.45, 95% CI 1.18 to 5.08; p=0.016).ConclusionsIn this general elderly population, glaucomatous optic disc was significantly associated with higher prevalence of depressive symptoms independent of a number of potential confounding factors, including daily light exposure profiles.