The relationship between brain morphometry and neuropsychological performance in alcohol dependence
The relationship between brain morphometry and neuropsychological performance in alcohol dependence
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DOI：
10.1016/j.neulet.2007.09.047
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发表时间：
2007-11-20
影响因子：
2.5
通讯作者：
Lee, Eun
中科院分区：
文献类型：
--
作者：
Jang, Dong-Pyo;Namkoong, Kee;Lee, Eun
本研究的目的是探讨局部脑萎缩的酒精依赖患者使用基于体素的分析磁共振图像，并探讨这些萎缩的区域与饮酒史和神经心理学表现的关系。应用统计参数映射对20例酒精依赖患者和20例对照者的分割灰质和白色物质图像进行全局和区域比较。采用Rey言语学习测验、Rey-Osterrieth复杂图形测验、Stroop测验、线索形成测验和威斯康星州卡片分类测验进行神经心理学评价。在酒精依赖的全球范围内，灰质和白色物质均显著减少。尤其是双侧海马旁白色物质区减少。威斯康星州卡片分类测验中的持续反应和持续错误与左侧上级颞回和右侧中央后区的灰质减少显著相关。心理表现指标与灰质相关，而不是白色物质，而右颞白色物质与过去4周的饮酒量相关。这可能意味着大量饮酒会损害灰质和白色物质，灰质萎缩主要导致认知障碍，而白色物质与饮酒史有关。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history. (C) 2007 Elsevier Ireland Ltd. All rights reserved.