THE LONG-TERM EFFECTS OF PREFRONTAL LEUKOTOMY
THE LONG-TERM EFFECTS OF PREFRONTAL LEUKOTOMY
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DOI：
10.1001/archneur.1981.00510030059008
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发表时间：
1981-01-01
影响因子：
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通讯作者：
LEVINE, HL
中科院分区：
文献类型：
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作者：
BENSON, DF;STUSS, DT;LEVINE, HL
为了探讨双侧前额叶破坏的长期影响，对大约 25 年前接受过前额叶脑白质切除术的 16 名精神分裂症患者进行了神经系统检查、精神结果、EEC、计算机断层扫描 (CT) 和一系列神经心理学测试的研究。 5 名未进行白细胞切除的慢性精神分裂症患者和 5 名年龄匹配的正常受试者作为对照。提供了有关主题的详细信息的报告、测试程序的概要和长期残留物的概述。一般来说，CT显示的额叶病变越大，特别是不对称的情况下，精神结果越好，心理测试的表现也越好，但额叶病变大小与神经系统或脑电图异常之间没有相关性。
To explore the long-term effects of bilateral prefrontal destruction, 16 schizophrenics who had undergone prefrontal leukotomy approximately 25 yr earlier were studied by neurologic examination, psychiatric outcome, EEC, computerized tomography (CT) and a battery of neuropsychological tests. Five nonleukotomized chronic schizophrenics and 5 age-matched normal subjects served as controls. A report of the details on the subjects, an outline of the test procedures and an overview of the long-term residua are presented. In general, the larger the frontal lesion demonstrated by CT, particularly if asymmetric, the better the psychiatric outcome and the better the performance on psychological testing, but there was no correlation between frontal lesion size and either neurologic or EEG abnormality.