Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain
Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain
复制标题
成人大脑中存在胰岛素样生长因子 1 (IGF-1) 和 2 (IGF-2) 以及胰岛素特异性受体的证据
DOI：
10.1016/0304-3940(82)90089-1
复制
发表时间：
1982
影响因子：
2.5
通讯作者：
L. Wetterberg
中科院分区：
文献类型：
--
作者：
Vicki R. Saka;K. Hall;Hans Von Holtz;R. Humbel;Barbro Sjören;L. Wetterberg
本研究探讨成人脑组织中胰岛素样生长因子（IGFs）1和2和胰岛素受体的存在。所有激素的结合位点广泛分布在尸检时取出的大脑中，在各个皮质区域发现了最高的特异性结合。对额叶活检材料进行的交叉反应研究表明IGF-1和胰岛素的特异性结合位点，而碘化IGF-2同样被IGF-1和IGF-2取代，表明成人大脑中存在额外的IGF-2样结合位点。
The present study examines adult human brain tissue for the presence of receptors for insulin-like growth factors (IGFs) 1 and 2 and insulin. Binding sites for all hormones were widely distributed throughout the brain removed at autopsy, with the highest specific binding being found in the various cortical regions. Cross-reaction studies performed on frontal lobe biopsy material indicated specific binding sites for IGF-1 and insulin whereas iodinated IGF-2 was equally displaced by IGF-1 and IGF-2, suggesting the presence of an additional IGF-2-like binding site in the adult brain.