F-18FDG PET/CT evaluation of osseous and soft tissue sarcomas
F-18FDG PET/CT evaluation of osseous and soft tissue sarcomas
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DOI：
10.1097/01.rlu.0000246846.01492.31
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发表时间：
2006-12-01
影响因子：
10.6
通讯作者：
Gambhir, Sanjiv S.
中科院分区：
文献类型：
--
作者：
Iagaru, Andrei;Quon, Andrew;Gambhir, Sanjiv S.
前言：骨与软组织肉瘤（OSTS）是一组组织学异质性的恶性肿瘤。目前大多数关于F-18 FDG PET在肉瘤中作用的临床数据来自使用专用PET研究的患者，而较少使用硬件融合PET/CT。因此，我们被提示审查我们的经验与F-18 FDG PET/CT在OSTS.Methods：这是一项回顾性研究（2003年1月至2005年12月）的44例组织学诊断OSTS谁有F-18 FDG PET/CT在我们的机构。该组包括22名男性和22名女性，年龄范围为2 - 84岁（平均37 +/- 20.2岁）。F-18 FDG的给药剂量范围为4.1至19.5 mCi（平均14.3 +/- 3 mCi）。重新解释影像学研究的准确性和数据分析从医疗记录进行。结果：F-18FDGPET/CT联合诊断的敏感性和特异性均为100%（95%置信区间[Cl] = 75.7-100）和93.3%原发性OSTS为80%（95%CI = 58.4 - 91.9），转移性OSTS为86.4%（95%CI = 66.7-95.2）。当单独解释时，CT在肺转移检测方面优于PET：CT的敏感性为76.5%，特异性为88%，而PET的敏感性仅为57.1%，特异性为96.4%。对于其他转移瘤的检测，CT是82.3%的敏感性和76%的特异性，与PET显示78.6%的敏感性和92.8%specificity.Conclusion：相对相似的结果（除了更好的特异性PET和PET/CT）时，注意到检查转移瘤的检测率，不包括肺部病变。然而，与单独PET相比，CT对肺转移瘤的检出率更高。PET扫描阴性的胸部可疑CT表现不能可靠地排除OSTS的肺转移。
Introduction: Osseous and soft tissue sarcomas (OSTS) represent a histologic heterogeneous group of malignant tumors. Most of the current clinical data on the role of F-18 FDG PET in sarcomas come from patients studied with dedicated PET and less frequently with hardware fusion PET/CT. Therefore, we were prompted to review our experience with F-18 FDG PET/CT in OSTS.Methods: This is a retrospective study (January 2003-December 2005) of 44 patients with histologic diagnoses of OSTS who had F-18 FDG PET/CT at our institution. The group included 22 men and 22 women with an age range of 2 of 84 years (average, 37 +/- 20.2 years). The administered doses of F-18 FDG range 4.1 to 19.5 mCi (average, 14.3 +/- 3 mCi). Reinterpretation of the imaging studies for accuracy and data analysis from medical records was performed.Results: The sensitivity and specificity of combined F-18 FDG PET/CT were 100% (95% confidence interval [Cl] = 75.7-100) and 93.3% (95% Cl = 78.7-98.1) for the primary OSTS, and 80% (95% CI = 58.4-91.9) and 86.4% (95% Cl = 66.7-95.2) for metastases. When interpreted separately, CT outperformed PET for pulmonary metastases detection: CT was 76.5% sensitive and 88% specific, whereas PET was only 57.1% sensitive but 96.4% specific. For detection of other metastases, CT was 82.3% sensitive and 76% specific, with PET demonstrating 78.6% sensitivity and 92.8% specificity.Conclusion: Relatively similar results (except better specificity for PET and PET/CT) were noted when examining the rate of metastases detection, excluding pulmonary lesions. However, CT had a better detection rate for pulmonary metastases when compared with PET alone. A negative PET scan in the presence of suspicious CT findings in the chest cannot reliably exclude pulmonary metastases from OSTS.