Association of oral estradiol dose/levels with coagulation measures in early/late postmenopausal women.
Association of oral estradiol dose/levels with coagulation measures in early/late postmenopausal women.
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DOI：
10.1080/13697137.2019.1703939
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Mack WJ
中科院分区：
文献类型：
--
作者：
Sriprasert I;Hodis HN;Bernick B;Mirkin S;Mack WJ
本研究评价了绝经早期（<6岁）和晚期（≥10岁）妇女雌二醇（E2）剂量和血清E2水平与凝血/抗凝措施的关系。来自REPLENISH试验的绝经后妇女测试了四种口服E2和孕酮联合制剂与安慰剂的比较。混合效应线性模型检测了E2剂量和血清E2水平与凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、抗凝血酶（ATHRM）、纤维蛋白原（FIBRINO）、蛋白C（PROTC）和蛋白S（PROTS）的相关性，在12个月内评估了5次。在1215名绝经早期和297名绝经晚期妇女中，E2剂量与绝经早期的APTT、绝经晚期的PROTC以及两组的PT、ATHRM和PROTS呈统计学显著负相关。血清E2水平与绝经早期APTT、PROTS、FIB、绝经晚期PT、ATHRM、PROTC呈负相关。随着绝经时间的延长，E2的剂量效应和血清E2效应的逆效应逐渐增强。增加E2剂量和血清E2水平与凝血/抗凝措施的变化相关。在绝经后≥10年的女性中，开始E2时的相关性更强。E2治疗的时机、E2剂量和血清E2水平相对于绝经后时间可能会改变静脉血栓栓塞的风险。
This study evaluated associations of estradiol (E2) dose and serum E2 levels with coagulation/anti-coagulation measures in early (<6 years) compared with late (≥10 years) postmenopausal women. Postmenopausal women from the REPLENISH trial tested four formulations of oral combined E2 and progesterone compared with placebo. Mixed-effects linear models tested the association of E2 dose and serum E2 levels with the prothrombin time (PT), the activated partial thromboplastin time (APTT), antithrombin (ATHRM), fibrinogen (FIBRINO), protein C (PROTC), and protein S (PROTS), assessed five times over 12 months. Among 1215 early and 297 late postmenopausal women, the E2 dose was statistically significantly inversely associated with the APTT in early postmenopause, PROTC in late postmenopause, and with the PT, ATHRM, and PROTS in both groups. Serum E2 levels were statistically significantly inversely associated with the APTT, PROTS, and FIBRINO in early postmenopause, the PT in late postmenopause, and ATHRM and PROTC in both groups. With longer time since menopause, the inverse E2 dose effect and serum E2 effects became stronger. Increasing E2 dose and serum E2 levels were associated with changes in coagulation/anti-coagulation measures. The associations were stronger among women ≥10 years since menopause when initiating E2. The timing of E2 therapy, E2 dose, and serum E2 levels relative to time since menopause may modify the venous thromboembolism risk.
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影响因子：
39.2
作者：
Grady, D;Wenger, NK;Hulley, S
通讯作者：
Hulley, S
影响因子：
2
作者：
Acs, N;Vajo, Z;Székåcs, B
通讯作者：
Székåcs, B
DOI：
10.1056/nejmoa1505241
发表时间：
2016-03-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodis HN;Mack WJ;Henderson VW;Shoupe D;Budoff MJ;Hwang-Levine J;Li Y;Feng M;Dustin L;Kono N;Stanczyk FZ;Selzer RH;Azen SP;ELITE Research Group
通讯作者：
ELITE Research Group
影响因子：
8.7
作者：
WILLIAMS, JK;ANTHONY, MS;CLARKSON, TB
通讯作者：
CLARKSON, TB
影响因子：
6.7
作者：
Winkler, UH;Altkemper, R;Bennink, HJTC
通讯作者：
Bennink, HJTC