Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
Metabolic changes, hypothalamo-pituitary-adrenal axis and oxidative stress after short-term starvation in healthy pregnant women
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健康孕妇短期饥饿后代谢变化、下丘脑-垂体-肾上腺轴和氧化应激
DOI：
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发表时间：
2007
影响因子：
2.4
通讯作者：
E. Beinder
中科院分区：
文献类型：
--
作者：
S. Schraag;U. Mandach;H. Schweer;E. Beinder
Abstract Aim: To compare metabolic effects and oxidative stress in pregnant and non-pregnant women after 12 h of fasting. Methods: Twenty-six healthy women with uncomplicated singleton pregnancies between the 24th and 28th gestational week were recruited. After an overnight fast, venous blood samples and urine samples were tested for metabolic parameters characteristic for starvation, cortisol and oxidative stress products. Healthy non-pregnant women matched by age, body mass index and length of fasting comprised the control group. Results: The metabolic parameters β-hydroxybutyrate and free fatty acids in blood and ketones in urine showed no differences in pregnant and non-pregnant women. However, the oxidative stress parameters, 8,12-iso-iPF2α-VI, isoprostanes and malondialdehyde were significantly higher in pregnant subjects, as was cortisol. Conclusion: Healthy pregnant women are exposed to oxidative stress and activation of the hypothalamo-pituitary-adrenal axis, but not to metabolic changes resembling starvation during short fasting periods in comparison to non-pregnant healthy women.
影响因子：
158.5
作者：
NESS, RB;HARRIS, T;DAGOSTINO, RB
通讯作者：
DAGOSTINO, RB
影响因子：
7.4
作者：
Roberts, LJ;Morrow, JD
通讯作者：
Morrow, JD
没有证据表明严重先兆子痫存在脂质过氧化。
影响因子：
9.8
作者：
Regan,CL;Levine,RJ;Baird,DD;Ewell,MG;Martz,KL;Sibai,BM;Rokach,J;Lawson,JA;Fitzgerald,GA
通讯作者：
Fitzgerald,GA