Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1
Evolutionary origin of pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1
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产肠毒素大肠杆菌和霍乱弧菌O1致病决定因素的进化起源
DOI：
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发表时间：
1987
影响因子：
3.2
通讯作者：
Takeshi Yokota
中科院分区：
文献类型：
--
作者：
Tatsuo;Yamamoto;Takashi Gojobori;Takeshi Yokota
肠致病性大肠杆菌和霍乱弧菌O1中进化相关的致病决定簇的三个家族，霍乱肠毒素（CT）和热不稳定肠毒素（LT）家族，包括CT、LTh和LTp，热稳定肠毒素I（STI）家族，包括STIa和STIb，以及K88肠粘附菌毛家族，包括K88ab、K88ac，和K88ad的同义（沉默）核苷酸替换进行了分析，利用先前报道的基因核苷酸序列和本文提供的LTp基因核苷酸序列。这些数据表明，LT和CT之间的分歧和STIa和STIb之间发生在遥远的过去，而LTh和LTp之间的分歧和K88家族成员之间的分歧发生在最近。我们认为LT基因是大肠杆菌获得的外源基因。大肠杆菌形成肠道病原体。这提供了原核生物中致病性决定因素种间转移的进化证据。
Three families of the evolutionarily related pathogenic determinants in enterotoxigenic Escherichia coli and Vibrio cholerae O1, a family of cholera enterotoxin (CT) and heat-labile enterotoxin (LT) including CT, LTh, and LTp, a family of heat-stable enterotoxin I (STI) including STIa and STIb, and a family of K88 enteroadhesion fimbriae including K88ab, K88ac, and K88ad were analyzed for synonymous (silent) nucleotide substitutions by using the gene nucleotide sequences of earlier reports and the LTp gene nucleotide sequence presented in this paper. The data suggested that the divergences between LT and CT and between STIa and STIb occurred in the remote past, whereas those between LTh and LTp and between members of the K88 family occurred very recently. We concluded that the LT gene is a foreign gene that has been acquired by E. coli to form an enteropathogen. This provides evolutionary evidence of species-to-species transfer of pathogenic determinants in procaryotes.
DOI：
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发表时间：
1982-05
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
E. Spicer;J. A. Noble
通讯作者：
E. Spicer;J. A. Noble
编码 Eco RI 核酸内切酶和甲基化酶的 DNA 的序列分析。
DOI：
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发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Greene,PJ;Gupta,M;Boyer,HW;Brown,WE;Rosenberg,JM
通讯作者：
Rosenberg,JM
霍乱弧菌肠毒素A2和B亚基的核苷酸序列分析。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Lockman,H;Kaper,JB
通讯作者：
Kaper,JB