Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection
Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection
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DOI：
10.1016/j.urolonc.2010.01.005
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发表时间：
2012-03-01
影响因子：
2.7
通讯作者：
Fujisawa, Masato
中科院分区：
文献类型：
--
作者：
Muramaki, Mototsugu;Miyake, Hideaki;Fujisawa, Masato
本研究的目的是探讨E-cadherin和N-cadherin在新诊断的非肌肉侵袭性膀胱癌（NMIBC）中表达谱对经尿道膀胱切除术（TUR）患者膀胱内复发概率的影响。本研究纳入了连续115例TUR后诊断为NMIBC的患者。采用免疫组化染色法检测患者TUR标本中E-cadherin和N-cadherin的表达水平。在本研究中，115例患者中有35例膀胱内复发（30.4%）。免疫组化结果显示，E-cadherin阳性表达62例（53.9%），N-cadherin阳性表达48例（41.7%）。62例E-cadherin阳性表达患者中仅有7例（11.3%）膀胱内复发，而48例N-cadherin阳性表达患者中有33例（68.8%）膀胱内复发。根据E-cadherin和N-cadherin的表达阳性情况将患者分为4组，30例E-cadherin阴性和N-cadherin阳性患者中有27例（90.0%）出现膀胱内复发，且该组患者膀胱内无复发生存率明显低于其余3组。此外，在多变量分析中，E-cadherin阴性和N-cadherin阳性表达被确定为TUR后膀胱内复发的最强大的独立预测因子。这些结果表明，NMIBC中E-cadherin的缺失和N-cadherin表达的增加似乎与术后复发显著相关；因此，从E-cadherin到N-cadherin表达的转换可能参与了NMIBC膀胱内复发的机制。(C) 2012爱思唯尔公司版权所有。
The objective of this study was to investigate the impact of the expression profile of E-cadherin and N-cadherin in newly diagnosed non-muscle-invasive bladder cancer (NMIBC) on the probability of intravesical recurrence in patients undergoing transurethral resection (TUR). This study included 115 consecutive patients diagnosed as having NMIBC following TUR. Expression levels of E-cadherin and N-cadherin in TUR specimens from these patients were measured by immunohistochemical staining. In this series, intravesical recurrence occurred in 35 of 115 patients (30.4%). Immunohistochemical study showed that positive expression of E-cadherin and N-cadherin were noted in 62 (53.9%) and 48 (41.7%) specimens, respectively. Intravesical recurrence was detected in only 7 of 62 patients (11.3%) with positive E-cadherin expression, while 33 of 48 patients (68.8%) with positive N-cadherin expression developed intravesical recurrence. When patients were divided into 4 groups according to the positivities of E-cadherin and N-cadherin expression, intravesical recurrence was detected in 27 of 30 patients (90.0%) with negative E-cadherin as well as positive N-cadherin expression, and the intravesical recurrence-free survival of this group was significantly poorer than those of the remaining 3 groups. Furthermore, negative E-cadherin as well as positive N-cadherin expression was identified as the most powerful independent predictor for intravesical recurrence following TUR on multivariate analysis. These findings suggest that the loss of E-cadherin and gain of N-cadherin expression in on NMIBC appeared to be significantly associated with postoperative recurrence; therefore, the switch from E-cadherin to N-cadherin expression might be involved in the mechanism underlying intravesical recurrence of on NMIBC. (C) 2012 Elsevier Inc. All rights reserved.