Lifestyle factors and bone density in the elderly: Implications for osteoporosis prevention
Lifestyle factors and bone density in the elderly: Implications for osteoporosis prevention
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老年人的生活方式因素和骨密度：对预防骨质疏松症的影响
DOI：
10.1002/jbmr.5650090904
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发表时间：
1994
影响因子：
6.2
通讯作者：
J. Eisman
中科院分区：
文献类型：
--
作者：
Tuan V. Nguyen;P. Kelly;P. Sambrook;P. Sambrook;C. Gilbert;N. Pocock;J. Eisman
流行病学证据表明，生活方式因素，如运动，钙摄入量和烟草消费量，对骨密度有影响。然而，这些因素对老年人的影响还没有得到很好的记录。为了研究生活方式因素对老年人的影响，我们测量了参与杜博骨质疏松流行病学研究（DOES）的709名老年男性和1080名老年女性的腰椎和股骨近端骨密度（BMD），DOES是一项基于社区的60岁以上男性和女性骨质疏松症纵向流行病学研究。男性的BMD显著高于女性（所有部位均为20%）。两种性别的股骨颈和女性腰椎的BMD均出现年龄相关性下降。在60至80岁之间，女性股骨颈BMD下降18.9%，几乎是男性BMD下降（10.1%）的两倍。吸烟与两种性别两个部位的BMD降低相关（5 - 8%），这种影响与钙摄入量或体重无关。戒烟者的BMD介于当前吸烟者和从不吸烟者之间，表明烟草的影响部分可逆。股四头肌力量预测老年男性股骨近端的骨密度，但在女性中则不然。分析骨骼肌力量和钙摄入量三分位数的骨密度（经年龄和体重校正），发现钙摄入量和肌肉力量对骨密度的影响存在交互作用;无论男女，股四头肌力量和钙摄入量高的人股骨颈的骨密度比股四头肌力量和钙摄入量低的人高约5%（P <0. 05）。这些数据表明，生活方式因素，如烟草消费，钙摄入量和体育活动，可能会影响老年人的骨密度。这些生活方式因素的改变可能会影响老年男性和女性骨质疏松性骨折的风险。
Epidemiologic evidence suggests that lifestyle factors, such as exercise, calcium intake, and tobacco consumption, have effects on bone density. However, the influence of these factors in the elderly has not been well documented. To examine the effects of lifestyle factors in the elderly, we measured bone density (BMD) at the lumbar spine and proximal femur in 709 elderly men and 1080 women participating in the Dubbo Osteoporosis Epidemiology study (DOES), a community‐based, longitudinal, epidemiologic study of osteoporosis in men and women over the age of 60. BMD was significantly higher in men than in women (20% at all sites). There was an age‐related decline in BMD at the femoral neck in both sexes and at the lumbar spine in women. Between the ages of 60 and 80, the decrease in BMD at the femoral neck among women was 18.9%, which is almost twice the decrease in BMD among men (10.1%). Tobacco consumption was associated with a reduction in BMD at both sites in both sexes (5‐8%), and this effect was independent of calcium intake or body weight. Exsmokers had BMD intermediate between that of current smokers and never smokers, suggesting the influence of tobacco was partially reversible. Quadriceps strength predicted bone density at the proximal femur in elderly men but not in women. Analyzing BMD (adjusted for age and weight) in tertiles of muscle strength and calcium intake revealed an interaction between calcium intake and muscle strength on bone density; BMD at the femoral neck among those with higher quadriceps strength and calcium intake was approximately 5% higher (P < 0.05) than in those with low quadriceps strength and calcium intake in both men and women. These data indicate that lifestyle factors, such as tobacco consumption, calcium intake, and physical activity, may influence bone density in the elderly. Modification of these lifestyle factors may influence osteoporotic fracture risk in elderly men and women.
影响因子：
39.2
作者：
S. Ott;C. Chesnut
通讯作者：
S. Ott;C. Chesnut
影响因子：
15.9
作者：
RIGGS, BL;WAHNER, HW;MELTON, LJ
通讯作者：
MELTON, LJ