Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group
Surgery alone is sufficient therapy for children and adolescents with low-risk synovial sarcoma: A joint analysis from the European paediatric soft tissue sarcoma Study Group and the Children's Oncology Group
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DOI：
10.1016/j.ejca.2017.03.003
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发表时间：
2017-06-01
影响因子：
8.4
通讯作者：
Spunt, Sheri L.
中科院分区：
文献类型：
--
作者：
Ferrari, Andrea;Chi, Yueh-Yun;Spunt, Sheri L.
背景：多模式风险适应性治疗用于滑膜肉瘤（SS）的儿科方案。回顾性分析表明，低风险的SS患者可以安全地单独手术治疗，但没有前瞻性研究证实这种方法的安全性。该分析汇总了两项前瞻性临床试验的数据，以评估仅接受手术治疗的SS患者的结局，并确定治疗失败的预测因素。方法：参加欧洲儿科软组织肉瘤研究组（EpSSG）NRSTS 2005和儿童肿瘤组（COG）ARST 0332试验的局限性SS患者，仅接受手术治疗，有资格参加本分析。患者必须接受初始完全切除，组织学上无切缘，任何大小的2级肿瘤或3级肿瘤
Background: Multimodal risk-adapted treatment is used in paediatric protocols for synovial sarcoma (SS). Retrospective analyses suggest that low-risk SS patients can be safely treated with surgery alone, but no prospective studies have confirmed the safety of this approach. This analysis pooled data from the two prospective clinical trials to assess outcomes in SS patients treated with a surgery-only approach and to identify predictors of treatment failure.Methods: Patients with localised SS enrolled on the European paediatric Soft tissue sarcoma Study Group (EpSSG) NRSTS2005 and on the Children Oncology Group (COG) ARST0332 trials, treated with surgery alone were eligible for this analysis. Patients must have undergone initial complete resection with histologically free margins, with a grade 2 tumour of any size or a grade 3 tumour