Introduction. Oxidative stress in mitochondria disorders of aging.
Introduction. Oxidative stress in mitochondria disorders of aging.
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DOI：
10.1159/000046872
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Ebadi,M
中科院分区：
文献类型：
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作者：
Ebadi,M
这些生物信号和受体的特殊问题是为了描述线粒体DNA损伤，氧化应激和人类疾病，包括神经退行性和神经肌肉疾病，与衰老有关的疾病，缺血-灌注损伤。传统上，线粒体被认为是细胞的“发电站”，即参与三磷酸腺苷（ATP）生产的氧化磷酸化机制的位点。因此，在过去的40年里，对线粒体进行的大部分研究都集中在阐明参与氧化磷酸化ATP合成的分子事件和参与氧化磷酸化机制生物发生的分子事件。虽然在研究这些对大多数动物细胞的生命至关重要的显着但极其复杂的过程方面已经取得了巨大成就，并将继续取得巨大成就，但直到近年来，大量生物和生物医学科学家才开始认识到线粒体参与其他重要过程。其中两个是细胞死亡和衰老，这并不奇怪，这两个过程都涉及部分氧化磷酸化机制。这种新的认识引发了线粒体研究的一个新的和不断增长的领域，这已经成为各种科学家的极大兴趣，从那些参与阐明线粒体在细胞死亡和衰老中的作用的科学家到那些对抑制或促进这些过程感兴趣的科学家，因为它涉及到识别人类疾病的新疗法或药物。
These special issues of Biological Signals and Receptors are intended to describe mitochondrial DNA damage, oxidative stress and human diseases, including neurodegenerative and neuromuscular diseases, disorders associated with aging, and ischemia-perfusion injury. Traditionally, mitochondria have been viewed as the'powerhouse'of the cell, ie, the site of the oxidative phosphorylation machinery involved in adenosine triphosphate (ATP) production. Consequently, much of the research conducted on mitochondria over the past 4 decades has focused on elucidating both those molecular events involved in ATP synthesis by oxidative phosphorylation and those involved in the biogenesis of the oxidative phosphorylation machinery. While monumental achievements have been made, and continue to be made, in the study of these remarkable but extremely complex processes essential for the life of most animal cells, it has been only in recent years that a large body of biological and biomedical scientists have come to recognize that mitochondria participate in other important processes. Two of these are cell death and aging which, not surprisingly, are related processes both involving, in part, the oxidative phosphorylation machinery. This new awareness has sparked a new and growing area of mitochondrial research that has become of great interest to a wide variety of scientists ranging from those involved in elucidating the role of mitochondria in cell death and aging to those interested in either suppressing or facilitating these processes as it relates to identifying new therapies or drugs for human disease.