Effects of [sar1, Ile8]-angiotensin II on rostral ventrolateral medulla neurons and blood pressure in spontaneously hypertensive rats
Effects of [sar1, Ile8]-angiotensin II on rostral ventrolateral medulla neurons and blood pressure in spontaneously hypertensive rats
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[sar1,Ile8]-血管紧张素II对自发性高血压大鼠延髓头侧腹外侧神经元及血压的影响
DOI：
10.1016/0306-4522(94)90021-3
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发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
T. Wong
中科院分区：
文献类型：
--
作者：
R. Chan;Y. Chan;T. Wong
本研究试图确定脑血管紧张素II对自发性高血压大鼠鼻侧腹外侧髓质心血管神经元自发活动的影响，已知其活性在自发性高血压大鼠中较高。在戊巴比妥麻醉的自发性高血压大鼠及其正常血压对照Wistar Kyoto大鼠中，微注射血管紧张素II拮抗剂[Sar1， Ile8]-血管紧张素II （sarile）后，同时测量脊髓突出的吻侧腹外侧髓质心血管神经元的自发活动和动脉血压。我们开发了一种显微注射方法，使我们能够在向神经元附近显微注射药物的过程中对延髓吻侧腹外侧心血管神经元进行细胞外记录。结果表明，沙乐降低了部分延髓吻侧腹外侧心血管神经元的动脉血压和放电率，呈剂量依赖性。沙乐对自发性高血压大鼠的作用明显大于Wistar Kyoto大鼠。本研究结果表明，自发性高血压大鼠延髓吻侧腹外侧心血管神经元对内源性脑血管紧张素II的敏感性增强。自发性高血压大鼠对脑血管紧张素II敏感性的增加可能有助于增强吻侧腹外侧髓质心血管神经元的自发活动，即使在静息或预刺激状态下也是如此，就像在反应性单一放电单元中一样。这种脑血管紧张素II和延髓吻侧腹外侧心血管神经元的相互作用可能是该品系大鼠高血压发生的原因之一。
The present study was an attempt to determine the influence of brain angiotensin II, the activity of which is known to be higher in spontaneously hypertensive rat, on the spontaneous activity of the cardiovascular neurons in the rostral ventrolateral medulla of the spontaneously hypertensive rat. Both the spontaneous activity of the spinal projecting rostral ventrolateral medulla cardiovascular neurons and the arterial blood pressure were simultaneously measured in the pentobarbital-anesthetized spontaneously hypertensive rat and its normotensive control, the Wistar Kyoto rat, following microinjection to rostral ventrolateral medulla of an angiotensin II antagonist, [Sar1, Ile8]-angiotensin II (sarile). A microinjection method was developed that enabled us to perform extracellular recording of the rostral ventrolateral medulla cardiovascular neuron during the microinjection of drug to the vicinity of the neuron. It was found that sarile reduced both the arterial blood pressure and firing rate of some rostral ventrolateral medulla cardiovascular neurons dose-dependently. The effects of sarile were significantly greater in spontaneously hypertensive rat than in the Wistar Kyoto rat.The present findings indicate that the rostral ventrolateral medulla cardiovascular neurons of spontaneously hypertensive rat exhibit an augmented sensitivity to endogenous brain angiotensin II. Such an increase in sensitivity to brain angiotensin II in the spontaneously hypertensive rat may contribute to the enhanced spontaneous activities of rostral ventrolateral medulla cardiovascular neurons, as in the sarile responsive single discharge units, even in the resting or prestimulation state. This interaction of brain angiotensin II and rostral ventrolateral medulla cardiovascular neurons is likely to be contributory to the genesis of hypertension in this strain of rats.
苯二氮卓反向激动剂 Ro 15-4513 和 FG 7142 对抗乙醇对小脑浦肯野神经元的作用：电生理学研究。
DOI：
--
发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Palmer,MR;vanHorne,CG;Harlan,JT;Moore,EA
通讯作者：
Moore,EA