Zinc-Catalyzed Alkyne-Carbonyl Metathesis of Ynamides with Isatins: Stereoselective Access to Fully Substituted Alkenes
Zinc-Catalyzed Alkyne-Carbonyl Metathesis of Ynamides with Isatins: Stereoselective Access to Fully Substituted Alkenes
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DOI：
10.1021/acs.joc.9b02350
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发表时间：
2019-12-06
影响因子：
3.6
通讯作者：
Hu, Wenhao
中科院分区：
文献类型：
--
作者：
Ao, Chaoqun;Yang, Xiaohan;Hu, Wenhao
研究了锌催化的氨基酰胺与isatins分子间炔羰基复分解反应，并由酰胺转化为酯，得到了收率较高的含全取代烯烃的吲哚酮衍生物。该反应的显著特点包括：反应条件温和，锌催化剂价格低廉，底物范围广，区域控制性和立体选择性好，且符合克尺度。
A zinc-catalyzed intermolecular alkyne carbonyl metathesis reaction of ynamides with isatins followed by an amide to ester conversion has been developed, which produces the indolone derivatives with a fully substituted alkene species in good to high yields. The salient features of this reaction include the following: mild reaction conditions, an inexpensive zinc catalyst, a broad substrate scope, the excellent regiocontrol and stereoselectivity, and amenable to the gram scale.