HISTIOCYTOID HEMANGIOMAS - UNIFYING CONCEPT EMBRACING SEVERAL PREVIOUSLY DESCRIBED ENTITIES OF SKIN, SOFT-TISSUE, LARGE VESSELS, BONE, AND HEART
HISTIOCYTOID HEMANGIOMAS - UNIFYING CONCEPT EMBRACING SEVERAL PREVIOUSLY DESCRIBED ENTITIES OF SKIN, SOFT-TISSUE, LARGE VESSELS, BONE, AND HEART
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DOI：
10.1016/s0046-8177(79)80114-8
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发表时间：
1979-01-01
期刊：
影响因子：
3.3
通讯作者：
LANDY, R
中科院分区：
文献类型：
--
作者：
ROSAI, J;GOLD, J;LANDY, R
有人提出，许多先前描述的皮肤、软组织、大血管、骨骼和心脏实体实际上构成了同一基本过程的不同表现，其特征是高度独特的细胞类型的增殖，描述性地鉴定为组织细胞样内皮细胞。所讨论的实体是血管淋巴样增生伴嗜酸性粒细胞增多和相关的皮肤和皮下疾病、大血管的非典型血管增殖、骨血管内皮瘤和心脏心内膜良性血管网状瘤。在所有这些条件下增殖的主要细胞具有内皮细胞的基本特征，但也表现出更类似于组织细胞的组织化学和超微结构特征。这些不寻常的特征可能是形态异常的表现，或者代表特定且尚未定义的内皮细胞亚群的过度生长，例如马伊诺氏收缩性内皮细胞。这组增殖性疾病是否具有反应性或肿瘤性性质尚不清楚，尽管后者似乎更有可能。作为一个整体，这些病变的行为是相当惰性的，甚至是自限性的，与真正的血管肉瘤的侵袭行为和常常致命的结果相反，它们在微观上非常相似。建议用组织细胞样血管瘤一词来形容这组[人类]疾病。
The proposal is made that a number of previously described entities of skin, soft tissue, large vessels, bone and heart actually constitute different manifestations of the same basic process, characterized by the proliferation of a highly distinctive type of cell descriptively identified as a histiocytoid endothelial cell. The entities in question are angiolymphoid hyperplasia with eosinophilia and related cutaneous and subcutaneous disorders, atypical vascular proliferation of large vessels, hemangioendothelioma of bone and endocardial benign angioreticuloma of the heart. The main cell that proliferates in all these conditions has the basic features of an endothelial cell but also exhibits histochemical and ultrastructural characteristics that are more akin to those of a histiocyte. These unusual features could be the expression of a morphologic abnormality or represent an overgrowth of a specific and as yet undefined subpopulation of endothelial cells, such as Majno''s contractile endothelial cell. Whether this group of proliferative diseases is of a reactive or a neoplastic nature is not immediately apparent, although the latter seems more likely. The behavior of these lesions, as a group, is quite indolent and even self-limited, in contrast to the aggressive behavior and often fatal outcome of the true angiosarcomas that they so closely resemble on microscopic grounds. The term histiocytoid hemangioma is suggested for this group of [human] disorders.