Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative.
Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative.
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DOI：
10.1007/s00330-015-3977-8
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发表时间：
2016-06
影响因子：
5.9
通讯作者：
OAI Investigators
中科院分区：
文献类型：
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作者：
Eckstein F;Boudreau R;Wang Z;Hannon MJ;Duryea J;Wirth W;Cotofana S;Guermazi A;Roemer F;Nevitt M;John MR;Ladel C;Sharma L;Hunter DJ;Kwoh CK;OAI Investigators
评价固定位置测量的放射学关节间隙宽度（JSW）和MRI软骨厚度的变化是否可预测膝关节置换术。在骨关节炎倡议中，在36-60个月随访（M）期间置换的膝关节均与一个对照组的年龄、性别和影像学状态相匹配。通过固定屈曲X线片确定影像学JSW，通过3特斯拉MRI确定次区域股胫软骨厚度。使用条件logistic回归比较置换前年度访视（T0）与T0前2年（T-2）之间的变化。研究了102名参与者的119个膝关节（55.5%为女性;年龄64.2±8.7 [平均值±标准差]）。置换膝关节和对照膝关节之间固定位置JSW从内侧到外侧的变化为22.5%（病例对照[cc] OR=1.57; 95%CI：1.23，2.01），其差异大于最小内侧JSW变化（ccOR=1.38; 95%CI：1.11，1.71）。内侧股胫软骨损失显示类似于最小JSW的歧视，和中央胫骨软骨损失类似于固定位置JSW。膝关节置换术前，位置无关性变薄和增厚评分均升高。对于固定位置，膝关节置换前病例与对照组之间的结构进展区分比最小影像学JSW更强。MRI显示与X线片相似的辨别力，并提示膝关节置换术前软骨增厚和丢失更严重。
To evaluate whether change in fixed location measures of radiographic joint space width (JSW) and in cartilage thickness by MRI predict knee replacement. Knees replaced between 36-60 months follow-up (M) in the Osteoarthritis Initiative were each matched with one control by age, sex, and radiographic status. Radiographic JSW was determined from fixed flexion radiographs, and subregional femorotibial cartilage thickness from 3 Tesla MRI. Changes between the annual visit before replacement (T0) and 2 years before T0 (T-2) were compared using conditional logistic regression. One hundred and nineteen knees from 102 participants (55.5% women; age 64.2±8.7 [mean±SD]) were studied. Fixed location JSW change at 22.5% from medial to lateral differed more between replaced and control knees (case-control [cc] OR=1.57; 95%CI: 1.23,2.01) than minimum medial JSW change (ccOR=1.38; 95%CI: 1.11,1.71). Medial femorotibial cartilage loss displayed discrimination similar to minimum JSW, and central tibial cartilage loss similar to fixed location JSW. Location-independent thinning and thickening scores were both elevated prior to knee replacement. Discrimination of structural progression between knee pre-placement cases versus controls was stronger for fixed-location than for minimum radiographic JSW. MRI displayed similar discrimination to radiography and suggested greater simultaneous cartilage thickening and loss prior to knee replacement.