Hydration and Orientation of Carbonyl Groups in Oppositely Charged Lipid Monolayers on Water
Hydration and Orientation of Carbonyl Groups in Oppositely Charged Lipid Monolayers on Water
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DOI：
10.1021/acs.jpcb.8b12297
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发表时间：
2019-02-07
影响因子：
3.3
通讯作者：
Backus, E. H. G.
中科院分区：
文献类型：
--
作者：
Dreier, L. B.;Bonn, M.;Backus, E. H. G.
水的甘油脂单层的羰基在界面氢键网络的形成中起着重要作用，这反过来又影响脂质与代谢物的相互作用。由于羰基吸收带的频率强烈依赖于脂质头基的水合状态，因此羰基吸收带是头基环境变化的敏感报告者。在这里，我们使用相分辨和频率产生光谱来获得关于脂质单层中羰基的取向和水合作用的信息。我们发现在脂质单分子层中有两个不同的羰基基团，相对于表面平面相反，经历了本质上不同的氢键环境。
The carbonyl groups of glycerolipid monolayers on water play an important role in the formation of the interfacial hydrogen bond network, which in turn influences the interactions of lipids with, for example, metabolites. As the frequency of the carbonyl absorption band strongly depends on the hydration state of the lipid headgroups, the carbonyl band is a sensitive reporter of changes in the headgroup environment. Here, we use phase-resolved sum frequency generation spectroscopy to obtain information about the orientation and hydration of the carbonyl groups in lipid monolayers. We find that there are two distinct carbonyl moieties in the lipid monolayers, oppositely oriented relative to the surface plane, that experience substantially different hydrogen-bonding environments.