Topographic localization of neuromedin u-like structures in the rat brain: An immunohistochemical study
Topographic localization of neuromedin u-like structures in the rat brain: An immunohistochemical study
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大鼠大脑中神经调节素 U 样结构的拓扑定位：一项免疫组织化学研究
DOI：
10.1016/0306-4522(87)90185-0
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发表时间：
1987
期刊：
影响因子：
3.3
通讯作者：
H. Matsuo
中科院分区：
文献类型：
--
作者：
M. Honzawa;T. Sudoh;N. Minamino;Masaya Tohyama;H. Matsuo
用间接免疫荧光法研究了在猪脊髓中发现的促子宫收缩和促血压肽神经介肽Us在大鼠脑内的分布。Neuromedin U样免疫反应性结构被发现是不均匀分布在神经元系统。Neuromedin U阳性神经元分布于颅运动核、网状核、前庭外侧核、三叉神经感觉核、上级和下丘、外侧丘系、脑桥核、红核、不定核、无名质、斜角带水平支和大脑皮质，形成具有不同免疫反应强度的纤维丛。此外，在丘脑网状核、腹后内侧核、腹后外侧核、被盖背侧核和腹侧核、斜角带垂直支、橄榄上级核和脑桥核也可见密集神经丛。在前六个结构中，没有标记的神经元，在其余的结构中，注意到一些分散的神经元。这表明这些纤维可能是外源性的。
The distribution of neuromedin Us, uterus-stimulating and hypertensive peptides newly identified in porcine spinal cord, was examined in the rat brain by the indirect immunofluorescent method. Neuromedin U-like immunoreactive structures were found to be unevenly distributed in the neuronal system. Neuromedin U-like immunoreactive neurons were present in the cranial motor nuclei, reticular nuclei, nucleus vestibularis lateralis, trigeminal sensory nuclei, colliculus superior and inferior, lemniscus lateralis, nucleus pontis, nucleus ruber, zona incerta, substantia innominata, horizontal limb of the diagonal band and cerebral cortex.The immunoreactive fibres were found in the above areas, particularly near the labelled cells, forming a fibre plexus with various intensities of immunoreactivity. In addition, dense plexuses were also seen in the nucleus reticularis thalami, nucleus ventralis posteromedialis, nucleus ventralis posterolateralis, nucleus tegmentalis dorsalis and ventralis, vertical limb of the diagonal band, nucleus olivaris superior, and nucleus pontis. In the first six structures, no labelled neurons were present and in the remaining structures, a few scattered neurons were noted. This indicates that these fibres are probably of extrinsic origin.