Training-induced alterations of carbohydrate metabolism in women: women respond differently from men
Training-induced alterations of carbohydrate metabolism in women: women respond differently from men
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DOI：
10.1152/jappl.1998.85.3.1175
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发表时间：
1998-09-01
影响因子：
3.3
通讯作者：
Brooks, GA
中科院分区：
文献类型：
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作者：
Friedlander, AL;Casazza, GA;Brooks, GA
我们在健康女性受试者(n=17；年龄23.8+/-2.0岁)中验证了葡萄糖流量与相对运动强度直接相关的假说[5天/周，持续1小时，75%峰值氧耗((V)/点氧(峰值))]。对9名受试者进行了两次训练前试验(45%和65%的(V)超过点O-2(峰值))和两次训练后的试验[相同的绝对负荷(旧(V)的65%比点O-2(峰值))和相同的相对负荷(新的(V)比点O-2(峰值)的65%)]。另外8名受试者使用[6，6-H-2]葡萄糖进行研究。受试者进行90min的休息和1h的自行车运动后的吸收研究。训练后，受试者对点O-2(峰值)的(V)增加了25.2+/-2.4%。训练前45%~65%VO2(峰值)的强度对血糖动力学的影响明显，出现率(R-a：4.52+/-0.25比5.53+/-0.33 mg·kg(-1)·min(-1))，消失(R-d：4.46+/-0.25比5.54+/-0.33 mg·kg(-1)·min(-1))，而葡萄糖的氧化(R-ox：2.45+/-0.16 vs.4.35+/-0.26 mg·kg(-1)·min(-1))在65%的试验中显著高于45%的试验(P<0.05)。在相同的绝对负荷下(P<0.05)，训练使R-a(4.7+/-0.30 mg·kg(-1).min(-1))、R-d(4.69+/-0.20 mg.kg(-1).min(-1))和R-ox(3.54+/-0.50 mg.kg(-1).min(-1))降低。当受试者在相同的相对工作负荷下进行测试时，训练后的R-a、R-d和R-ox没有显著差异。然而，在训练后的两种负荷下，由呼吸交换率确定的总碳水化合物氧化显著减少。这些结果表明，在年轻女性中：1)葡萄糖使用与运动强度直接相关；2)训练降低了给定功率输出的葡萄糖流量；3)当表示为相对运动强度时，训练不影响运动期间血糖流量的大小；但4)训练确实减少了总碳水化合物的氧化。
We examined the hypothesis that glucose flux was directly related to relative exercise intensity both before and after a 12-wk cycle ergometer training program [5 days/wk, 1-h duration, 75% peak O-2 consumption ((V) over dot O-2 (peak))] in healthy female subjects (n = 17; age 23.8 +/- 2.0 yr). Two pretraining trials (45 and 65% of (V) over dot O-2 (peak)) and two posttraining trials [same absolute workload (65% of old (V) over dot O-2 (peak)) and same relative workload (65% of new (V) over dot O-2 (peak))] were performed on nine subjects by using a primed-continuous infusion of [1-C-13]- and [6,6-H-2]glucose. Eight additional subjects were studied by using [6,6-H-2]glucose. Subjects were studied postabsorption for 90 min of rest and 1 h of cycling exercise. After training, subjects increased (V) over dot O-2 (peak) by 25.2 +/- 2.4%. Pretraining, the intensity effect on glucose kinetics was evident between 45 and 65% of VO2 (peak) with rates of appearance (R-a: 4.52 +/- 0.25 vs. 5.53 +/- 0.33 mg.kg(-1).min(-1)), disappearance (R-d: 4.46 +/- 0.25 vs. 5.54 +/- 0.33 mg.kg(-1).min(-1)), and oxidation (R-ox: 2.45 +/- 0.16 vs. 4.35 +/- 0.26 mg.kg(-1).min(-1)) of glucose being significantly greater (P less than or equal to 0.05) in the 65% than in the 45% trial. Training reduced R-a (4.7 +/- 0.30 mg.kg(-1).min(-1)), R-d (4.69 +/- 0.20 mg.kg(-1).min(-1)), and R-ox (3.54 +/- 0.50 mg.kg(-1).min(-1)) at the same absolute workload (P less than or equal to 0.05). When subjects were tested at the same relative workload, R-a, R-d, and R-ox were not significantly different after training. However, at both workloads after training, there was a significant decrease in total carbohydrate oxidation as determined by the respiratory exchange ratio. These results show the following in young women: 1) glucose use is directly related to exercise intensity; 2) training decreases glucose flux for a given power output; 3) when expressed as relative exercise intensity, training does not affect the magnitude of blood glucose flux during exercise; but 4) training does reduce total carbohydrate oxidation.