ELEVATED CONCENTRATIONS OF CSF CORTICOTROPIN-RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN DEPRESSED-PATIENTS
ELEVATED CONCENTRATIONS OF CSF CORTICOTROPIN-RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN DEPRESSED-PATIENTS
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DOI：
10.1126/science.6334362
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
VALE, W
中科院分区：
文献类型：
--
作者：
NEMEROFF, CB;WIDERLOV, E;VALE, W
通过测定正常健康志愿者和DSM-III [精神疾病诊断和统计手册]诊断为抑郁症、精神分裂症或痴呆的无药物患者CSF中促肾上腺皮质激素释放因子（CRF）的浓度，研究了在抑郁症患者中观察到的下丘脑-垂体-肾上腺轴过度活动中CRF分泌过多的可能性。当与对照组和其他诊断组相比，抑郁症患者表现出显着增加CSF浓度的CRF样免疫反应性，在11的23名抑郁症患者的免疫反应性大于正常对照组的最高值。CRF分泌过多至少部分是下丘脑-垂体-肾上腺轴过度活跃的原因，这一假说得到了结果的支持。
The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in CSF of normal healthy volunteers and in drug-free patients with DSM-III [Diagnostic and Statistical Manual of Mental Disorders] diagnoses of major depression, schizophrenia, or dementia. When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased CSF concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. The hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression was supported by the results.