Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
复制标题
DOI：
10.1016/j.neuroimage.2008.07.053
复制
发表时间：
2008-11-15
期刊：
影响因子：
5.7
通讯作者：
Ourselin, Sebastien
中科院分区：
文献类型：
--
作者：
Fripp, Jurgen;Bourgeat, Pierrick;Ourselin, Sebastien
β-淀粉样蛋白（A β）沉积是阿尔茨海默病（AD）的神经病理学标志之一，A β负荷可以使用C-11 PiB PET定量。神经病理学研究表明，最初的斑块位于颞叶和眶额皮质，随后延伸至扣带回、额叶和顶叶皮质（Braak and Braak，1997）。先前的研究表明，AD、轻度认知障碍（MCI）患者和正常老年对照（NC）参与者之间的C-11 PiB PET保留存在重叠。它也已被证明，有一个A β沉积和记忆障碍在MCI patient.In本文中，我们探讨了在15 AD，15 MCI和18 NC的空间和摄取归一化的PiB图像的体素数据建模的变异性，使用主成分分析。前两个主成分占数据中所见变异性的80%，提供了AD和NC之间的明确分离，并允许随后的分类。MCI病例沿着AD组和NC组之间的表观轴分布，与第一主成分轴紧密对齐。PiB（+）的NC病例形成了一个独特的簇，该簇位于AD和PiB（-）NC簇之间，但与AD和PiB（-）NC簇分开。发现PiB（+）MCI与AD病例聚集在一起，并表现出相似的沉积模式。发现主要主成分评分与情景记忆评分和简易精神状态检查相关，并且观察到通过改变第一主成分，可以推导出淀粉样蛋白沉积的变化，其类似于从尸检研究中观察到的淀粉样蛋白沉积的预期进展。(C)2008年爱思唯尔公司All rights reserved.
beta-amyloid (A beta) deposition is one of the neuropathological hallmarks of Alzheimer's disease (AD), A beta burden can be quantified using C-11 PiB PET. Neuropathological studies have shown that the initial plaques are located in the temporal and orbitofrontal cortices, extending later to the cingulate, frontal and parietal cortices (Braak and Braak, 1997). Previous studies have shown an overlap in C-11 PiB PET retention between AD, mild cognitive impairment (MCI) patients and normal elderly control (NC) participants. It has also been shown that there is a relationship between A beta deposition and memory impairment in MCI patients.In this paper we explored the variability seen in 15 AD, 15 MCI and 18 NC by modeling the voxel data from spatially and uptake normalized PiB images using principal component analysis. The first two principal components accounted for 80% of the variability seen in the data, providing a clear separation between AD and NC, and allowing subsequent classification. The MCI cases were distributed along an apparent axis between the AD and NC group, closely aligned with the first principal component axis. The NC cases that were PiB(+) formed a distinct cluster that was between, but separated from the AD and PiB(-)NC clusters. The PiB(+) MCI were found to cluster with the AD cases, and exhibited a similar deposition pattern. The primary principal component score was found to correlate with episodic memory scores and mini mental status examination and it was observed that by varying the first principal component, a change in amyloid deposition could be derived that is similar to the expected progression of amyloid deposition observed from post mortem studies. (C) 2008 Elsevier Inc. All rights reserved.