Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform
Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform
复制标题
DOI：
10.1117/1.jbo.17.6.061206
复制
发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Zhang, Hao F.
中科院分区：
文献类型：
--
作者：
Song, Wei;Wei, Qing;Zhang, Hao F.
光声眼科检查技术是一项新兴的视网膜成像技术，在一些致盲疾病的基础研究和临床诊断中都有前景。因此，将PAOM与其他现有眼科成像方式进行整合，对于识别和验证PAOM与现有技术相比的优势，为更全面的多模式成像提供基础，具有重要意义。为此，我们开发了一个将PAOM与扫描激光检眼镜（SLO）、光谱域光学相干断层扫描（SD-OCT）和荧光素血管造影（FA）相结合的视网膜成像平台。在该系统中，所有成像模式共享相同的光学扫描和传递机制，从而实现了所有模式的视网膜成像注册。在白化和色素化大鼠的眼睛中获得高分辨率PAOM、SD-OCT、SLO和FA图像。报道的体内结果表明，该集成系统能够提供基于多种光学对比的全面解剖成像。(C) 2012年中国光学仪器工程师学会。(jbo.17.6.061206 DOI: 10.1117/1.)
Photoacoustic ophthalmoscopy (PAOM) is a newly developed retinal imaging technology that holds promise for both fundamental investigation and clinical diagnosis of several blinding diseases. Hence, integrating PAOM with other existing ophthalmic imaging modalities is important to identify and verify the strengths of PAOM compared with the established technologies and to provide the foundation for more comprehensive multimodal imaging. To this end, we developed a retinal imaging platform integrating PAOM with scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA). In the system, all the imaging modalities shared the same optical scanning and delivery mechanisms, which enabled registered retinal imaging from all the modalities. High-resolution PAOM, SD-OCT, SLO, and FA images were acquired in both albino and pigmented rat eyes. The reported in vivo results demonstrate the capability of the integrated system to provide comprehensive anatomic imaging based on multiple optical contrasts. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061206]