PULMONARY SURFACE TENSION
PULMONARY SURFACE TENSION
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DOI：
10.1152/jappl.1959.14.5.717
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发表时间：
1959-01-01
影响因子：
3.3
通讯作者：
CLEMENTS, JA
中科院分区：
文献类型：
--
作者：
BROWN, ES;JOHNSON, RP;CLEMENTS, JA
根据P-V数据计算，肺表面张力在由放气引起的压力下显著降低，并且遵循与几个粘液表面非常相似的力-面积路径。当比表面积变化小于50%时，肺提取液和粘液泡表面是机械可逆的。对于面积减小大于50%的情况，表面张力接近10-15d/cm的较低极限张力。在表面再膨胀时，可获得40~50d/cm的上限张力。出现相当大的滞后，表明压缩超过50%的表面材料发生了重大变化。基于这些考虑对肺表面积的估计与组织学的估计一致。
The surface tension of the lung decreases markedly on compression resulting from deflation, as calculated from P-V data, and follows a force-area path very similar to that of several mucus surfaces. With changes in surface area of less than 50%, lung extract and mucus bubble surfaces are mechanically reversible. For decrease in area greater than 50%, surface tension approaches a lower limiting tension of 10-15 d/cm. On re-expansion of the surface, an upper limiting tension of 40-50 d/cm is approached. Hysteresis of considerable magnitude occurs and indicates a major alteration of the surface materials compressed beyond 50%. Estimates of lung surface area based on these considerations accord with histologic estimates.