Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study
Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study
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DOI：
10.1186/s12199-019-0836-2
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发表时间：
2019-12-28
影响因子：
4.7
通讯作者：
Maeda, Takahiro
中科院分区：
文献类型：
--
作者：
Shimizu, Yuji;Yamanashi, Hirotomo;Maeda, Takahiro
背景人类T细胞白血病病毒1型(HTLV-1)刺激炎症活动。我们之前的研究显示，在造血活动水平低(网织红细胞水平反映的)的日本老年人中，无症状HTLV-1感染与晚期牙周炎呈正相关。由于低造血活性与低度炎症相关，而低度炎症与动脉粥样硬化相关，动脉粥样硬化的状态反过来可能决定这种关联的性质。方法对2016-2018年间参加口腔健康检查的907名60~99岁的日本老年人进行横断面研究。晚期牙周炎定义为牙周袋<6.0 mm。结果在研究人群中，295人(32.5%)发现动脉粥样硬化，定义为颈动脉内膜-中层厚度(CIMT)=1.1 mm。在有动脉粥样硬化的参与者中，HTLV-1感染与晚期牙周炎呈正相关，但在没有动脉粥样硬化的参与者中没有观察到显著的相关性。晚期牙周炎的已知危险因素(包括网织红细胞和CIMT)调整后的优势比(OR)和95%可信区间(CI)在动脉粥样硬化组分别为OR 2.01和95%CI 1.06~3.81，在非动脉粥样硬化组分别为OR 0.61和95%CI 0.34~1.12。结论在日本老年动脉粥样硬化患者中，HTLV-1感染与晚期牙周炎密切相关。然而，这种关联在没有动脉粥样硬化的个体中是不存在的，这表明动脉粥样硬化可能在日本老年人HTLV-1感染和晚期牙周炎之间的关联中起决定性作用。
Background Human T cell leukemia virus type-1 (HTLV-1) stimulates inflammation activity. Our previous study revealed a positive association between asymptomatic HTLV-1 infection and advanced periodontitis among elderly Japanese individuals with low levels of hematopoietic activity (reflected by reticulocyte levels). Since low hematopoietic activity has been correlated with low-grade inflammation and low-grade inflammation is associated with atherosclerosis, the status of atherosclerosis could, in turn, determine the nature of this association. Methods To this end, a cross-sectional study of 907 elderly Japanese individuals (aged 60-99 years), who had participated in dental health check-up during the period 2016-2018, was conducted. Advanced periodontitis was defined as periodontal pocket >= 6.0 mm. Results Among the study population, 295 (32.5%) were found to have atherosclerosis defined as a carotid intima-media thickness (CIMT) of >= 1.1 mm. HTLV-1 infection was positively associated with advanced periodontitis in participants with atherosclerosis, but no significant associations were observed among the participants without atherosclerosis. The known risk factors' (including reticulocyte and CIMT) adjusted odds ratio (OR) and 95% confidence interval (CI) of advanced periodontitis were OR 2.01 and 95% CI 1.06-3.81 for participants with atherosclerosis and OR 0.61 and 95% CI 0.34-1.12 for participants without atherosclerosis. Conclusion This study found a significant association between HTLV-1 infection and advanced periodontitis among elderly Japanese with atherosclerosis. However, this association is absent in individuals without atherosclerosis, suggesting that atherosclerosis might act as a determinant in the association between HTLV-1 infection and advanced periodontitis among elderly Japanese.