Decoupling action potential bias from cortical local field potentials.
Decoupling action potential bias from cortical local field potentials.
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DOI：
10.1155/2010/393019
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Shamma, Shihab A
中科院分区：
文献类型：
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作者：
David, Stephen V;Malaval, Nicolas;Shamma, Shihab A
神经生理学家最近开始对通过局部场电位（LFP）记录研究神经元群体活动感兴趣，这些记录也记录了单个神经元的活动。这种实验方法与早期的LFP研究不同，因为它使用高阻抗电极，也可以隔离单个神经元活动。这种研究的一个可能的复杂性是，孤立神经元的小子集的突触电位和动作电位可能对LFP信号的贡献不成比例，使附近较大神经元群体中的活动偏向于与这些神经元同步和共调。为了解决这个问题，我们使用线性滤波技术从LFP记录中去除与尖峰事件相关的特征。该过滤程序可应用于隔离良好的单个单元或多单元活动。我们说明了这种校正在模拟和从初级听觉皮层记录的尖峰数据的影响。我们发现，本地尖峰活动可以解释一个显着的一部分LFP功率在大多数记录网站，并表明，删除尖峰相关的组件可以影响测量的听觉调谐的LFP。
Neurophysiologists have recently become interested in studying neuronal population activity through local field potential (LFP) recordings during experiments that also record the activity of single neurons. This experimental approach differs from early LFP studies because it uses high impedence electrodes that can also isolate single neuron activity. A possible complication for such studies is that the synaptic potentials and action potentials of the small subset of isolated neurons may contribute disproportionately to the LFP signal, biasing activity in the larger nearby neuronal population to appear synchronous and cotuned with these neurons. To address this problem, we used linear filtering techniques to remove features correlated with spike events from LFP recordings. This filtering procedure can be applied for well-isolated single units or multiunit activity. We illustrate the effects of this correction in simulation and on spike data recorded from primary auditory cortex. We find that local spiking activity can explain a significant portion of LFP power at most recording sites and demonstrate that removing the spike-correlated component can affect measurements of auditory tuning of the LFP.